{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:01:28Z","timestamp":1790744488514,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15545459"],"award-info":[{"award-number":["15545459"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Chronic intestinal pseudo\u2010obstruction (<jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content>) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause. Intestinal decompression is a key treatment, but conventional method including a trans\u2010nasal small intestinal tube is invasive and painful. Therefore, a less invasive and tolerable new decompression method is urgently desired. We conducted a pilot study and assessed the efficacy and safety of percutaneous endoscopic gastro\u2010jejunostomy (<jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010J) decompression therapy in <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven definitive <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> patients (2 males and 5 females) were enrolled. All patients received <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010J decompression therapy. The number of days with any abdominal symptoms in a month (<jats:styled-content style=\"fixed-case\">NODASIM<\/jats:styled-content>), body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), serum albumin level (Alb), and small intestinal volume before and after <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010J were compared in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Percutaneous endoscopic gastro\u2010jejunostomy was well tolerated and oral intake improved in all patients. <jats:styled-content style=\"fixed-case\">NODASIM<\/jats:styled-content> has significantly decreased (24.3 vs 9.3\u00a0days\/months) and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\/Alb have significantly increased (14.9 vs 17.2\u00a0kg\/m<jats:sup>2<\/jats:sup> and 2.6 vs 3.8\u00a0g\/dL, respectively), whereas total volume of the small intestine has not significantly reduced (4.05 vs 2.59\u00a0L, <jats:italic>P<\/jats:italic>=.18). Reflux esophagitis and chemical dermatitis were observed in one case but was successfully treated conservatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Percutaneous endoscopic gastro\u2010jejunostomy decompression therapy can contribute greatly to improvement of abdominal symptoms and nutritional status in <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> patients. Although sufficient attention should be paid to acid reflux symptoms, <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010J has the potential to be a non\u2010invasive novel decompression therapy for <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> available at home. However, accumulation of more <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> patients and long\u2010term observation are needed (<jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>000017574).<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13127","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T09:34:47Z","timestamp":1497951287000},"source":"Crossref","is-referenced-by-count":34,"title":["Efficacy of percutaneous endoscopic gastro\u2010jejunostomy (<scp>PEG<\/scp>\u2010J) decompression therapy for patients with chronic intestinal pseudo\u2010obstruction (<scp>CIPO<\/scp>)"],"prefix":"10.1111","volume":"29","author":[{"given":"H.","family":"Ohkubo","sequence":"first","affiliation":[{"name":"Hepatology and Gastroenterology Division Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fuyuki","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology Division Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Arimoto","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology Division Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Higurashi","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology Division Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology Division Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Inoh","sequence":"additional","affiliation":[{"name":"Department of Medical Education Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Medical Education Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Inamori","sequence":"additional","affiliation":[{"name":"Department of Medical Education Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department of Radiology Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology Division Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,20]]},"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:13:11Z","timestamp":1696155191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/nmo.13127"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13127","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]},"article-number":"e13127"}}