{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:56:09Z","timestamp":1778511369524,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["607652"],"award-info":[{"award-number":["607652"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastro\u2010esophageal reflux can be the cause of chronic cough. In the assessment of the temporal association between reflux and cough, previous studies have used a two\u2010minute time window, based on studies in patients with heartburn. However, it remains unclear whether the optimal time window duration for the evaluation of reflux\u2010induced cough is two minutes as well. Therefore, we aimed to determine whether a two\u2010minute time window is optimal to diagnose reflux\u2010induced cough.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter study, 137 patients with chronic cough were evaluated using 24\u2010h <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010impedance\u2010pressure monitoring. Repetitive symptom association analysis was employed using an array of time windows of various duration. For each time window, the symptom association probability (<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>) and symptom index (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 4377 cough burst episodes and 5074 reflux episodes were detected. The number of patients with a positive <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content> increased with increasing window duration until a plateau was reached around a time window duration of 1.5\u00a0min. Similarly, the <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content> increased steeply until a window duration of about 2\u00a0min, after which a linear increase was seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>A two\u2010minute time window seems appropriate for evaluation of the relationship between reflux and chronic cough using 24\u2010h <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010impedance\u2010pressure monitoring. A time window duration of 30\u00a0s or 1\u00a0min is too short to diagnose patients with reflux\u2010induced cough accurately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13129","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T08:47:22Z","timestamp":1497430042000},"source":"Crossref","is-referenced-by-count":14,"title":["Reflux\u2010cough syndrome: Assessment of temporal association between reflux episodes and cough bursts"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-5812","authenticated-orcid":false,"given":"T. V. K.","family":"Herregods","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University Hospital Gasthuisberg University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University Hospital Gasthuisberg University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60595-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.80S"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200312000-00013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03255.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055418"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.050"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701580421"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.7.479"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.8.699"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90815-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090215"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087567"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536258"},{"issue":"4","key":"e_1_2_10_16_1","first-page":"358","article-title":"The symptom index: a clinically important parameter of ambulatory 24\u2010hour esophageal pH monitoring","volume":"83","author":"Wiener GJ","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.010"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00101006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.06.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60776-4"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:12:53Z","timestamp":1696155173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/nmo.13129"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13129","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]},"article-number":"e13129"}}