{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:13:24Z","timestamp":1791645204303,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr. Willmar Schwabe GmbH & Co. KG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) is a very common condition affecting more than 10% of the population. While there is no cure, a few drugs have been found to be effective for the relief of symptoms, although most are only effective in a subgroup of patients. We assess and compare the efficacy of a fixed peppermint\/caraway\u2010oil\u2010combination (Menthacarin) on symptoms and quality of life (QoL) in patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> symptoms consistent with epigastric pain syndrome (<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) and postprandial distress syndrome (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, double\u2010blind, multicenter trial, 114 outpatients with chronic or recurrent <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> were randomized and treated for 4\u00a0weeks with the proprietary peppermint\u2010 and caraway\u2010oil\u2010preparation Menthacarin or placebo (2\u00d71 capsule\/day). Improvement of abdominal pain and discomfort were used as co\u2010primary efficacy measures (scores measured with the validated Nepean Dyspepsia Index).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>After 2 and 4\u00a0weeks, active treatment was superior to placebo in alleviating symptoms consistent with <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> all &lt;.001). After 4\u00a0weeks of treatment, pain and discomfort scores improved by 7.6\u00b14.8 and 3.6\u00b12.5 points (full analysis set; mean\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) for Menthacarin and by 3.4\u00b14.3 and 1.3\u00b12.1 points for placebo, respectively. All secondary efficacy measures showed advantages for Menthacarin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Menthacarin is an effective therapy for the relief of pain and discomfort and improvement of disease\u2010specific QoL in patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and significantly improves symptoms consistent with <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13132","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T04:56:47Z","timestamp":1499749007000},"source":"Crossref","is-referenced-by-count":67,"title":["A randomized placebo\u2010controlled trial on the effects of Menthacarin, a proprietary peppermint\u2010 and caraway\u2010oil\u2010preparation, on symptoms and quality of life in patients with functional dyspepsia"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Rich","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"Faculty of Medicine &amp; Faculty of Health &amp; Behavioural Sciences University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"Faculty of Medicine &amp; Faculty of Health &amp; Behavioural Sciences University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Koloski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"Faculty of Medicine &amp; Faculty of Health &amp; Behavioural Sciences University of Queensland  Brisbane QLD Australia"},{"name":"Faculty of Health and Medicine University of Newcastle  Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Funk","sequence":"additional","affiliation":[{"name":"Clinical Research Department Dr. Willmar Schwabe GmbH &amp; Co. KG  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Stracke","sequence":"additional","affiliation":[{"name":"Clinical Research Department Dr. Willmar Schwabe GmbH &amp; Co. KG  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Clinical Research Department Dr. Willmar Schwabe GmbH &amp; Co. 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