{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:14:19Z","timestamp":1778030059008,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Infant colic (\n IC<\/jats:styled-content>\n ) is a prevalent physiological event of infants, which can disrupt the child's home environment. We aimed to investigate the effectiveness of a mixture of\n Matricariae chamomilla<\/jats:italic>\n L.,\n Melissa officinalis<\/jats:italic>\n L. and tyndallized\n Lactobacillus acidophilus<\/jats:italic>\n (\n HA<\/jats:styled-content>\n 122) compared with\n Lactobacillus reuteri<\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 and with simethicone for the treatment of\n IC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A multicenter randomized comparative study was conducted in infants with colic, according to Rome III criteria, who were randomly assigned to receive\n M.\u00a0chamomilla<\/jats:italic>\n L.,\n M.\u00a0officinalis<\/jats:italic>\n L. and tyndallized\n L.\u00a0acidophilus<\/jats:italic>\n (\n HA<\/jats:styled-content>\n 122) (Colimil\n \u00ae<\/jats:sup>\n Plus\n \u00ae<\/jats:sup>\n ; Milte Italia Spa, Milan, Italy) (Group A),\n L.\u00a0reuteri<\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 (Group B) and simethicone (Group C). Treatment was given to subjects for 28\u00a0days.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n One\u2010hundred and seventy\u2010six patients completed the study. Mean daily crying time at day 28 was significantly lower in group A (\u221244, 95% CI: \u221258 to \u221230,\n P<\/jats:italic>\n <.001) and group B (\u221235, 95% CI: \u221249 to \u221220,\n P<\/jats:italic>\n <.001) when compared to group C. No significant difference was observed between Group A and Group B (mean difference: \u22129\u00a0minutes, 95% CI \u221223 to +5,\n P<\/jats:italic>\n =.205). At day 28, 39 of 57 (68.4%) of infants in Group C responded to the treatment compared with 57 out of 60 patients (95%) of Group A and 51 out of 59 (86.4%) of Group B (\n P<\/jats:italic>\n <.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study suggests that administration of\n M.\u00a0chamomilla<\/jats:italic>\n L.,\n M.\u00a0officinalis<\/jats:italic>\n L. and tyndallized\n L.\u00a0acidophilus<\/jats:italic>\n (\n HA<\/jats:styled-content>\n 122) and\n L.\u00a0reuteri<\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 are significantly more effective than simethicone in\n IC<\/jats:styled-content>\n . Clinical Trial Registration: ClinicalTrials.gov:\n NCT<\/jats:styled-content>\n 02708238.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.13145","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T07:27:39Z","timestamp":1498807659000},"source":"Crossref","is-referenced-by-count":38,"title":["Efficacy of a standardized extract of\n Matricariae chamomilla<\/i>\n L.,\n Melissa officinalis<\/i>\n L. and tyndallized\n Lactobacillus acidophilus<\/i>\n (\n HA<\/scp>\n 122) in infantile colic: An open randomized controlled trial"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Martinelli","sequence":"first","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ummarino","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. P.","family":"Giugliano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sciorio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tortora","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bruzzese","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"De Giovanni","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics of the University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rutigliano","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics of the University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Valenti","sequence":"additional","affiliation":[{"name":"Endoscopy and Gastroenterology Unit Department of Pediatrics University of Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Romano","sequence":"additional","affiliation":[{"name":"Endoscopy and Gastroenterology Unit Department of Pediatrics University of Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Campanozzi","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics of the University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-1339","authenticated-orcid":false,"given":"A.","family":"Staiano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0775"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.5.398"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.065"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12943"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305562"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3180327b55"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2006.1.146"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.1.15"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808323116"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1222"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0433"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001075"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2098"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1668"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300971"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000231"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/981352"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.4.380"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000949"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.11.039"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2192"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.79103"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181ac935c"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2012.682123"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800051n"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0595-6"},{"key":"e_1_2_10_31_1","first-page":"77","article-title":"Biological 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