{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:30Z","timestamp":1787015850489,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Methusalem grant to JT from Leuven University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Disturbances of gastric motor function of functional dyspepsia (\n FD<\/jats:styled-content>\n ) have been implicated in the pathogenesis of the symptoms, and hence, motility modifying agents are considered for its treatment. Mirtazapine was recently shown to improve symptoms and increase nutrient tolerance in\n FD<\/jats:styled-content>\n patients with weight loss. We aim to evaluate the effect of mirtazapine on gastric sensorimotor function in healthy volunteers (\n HV<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010one\n HV<\/jats:styled-content>\n underwent an intragastric pressure (\n IGP<\/jats:styled-content>\n ) and barostat measurements on separate days before and after 3\u00a0weeks of placebo or mirtazapine (15\u00a0mg). Gastric compliance, sensitivity and accommodation (\n GA<\/jats:styled-content>\n ) measured by the barostat.\n GA<\/jats:styled-content>\n was quantitated as the difference (delta) in intra\u2010balloon volume before and after ingestion of 200\u00a0mL of a nutrient drink (\n ND<\/jats:styled-content>\n ).\n GA<\/jats:styled-content>\n measured by\n IGP<\/jats:styled-content>\n was quantitated as the drop of\n IGP<\/jats:styled-content>\n from baseline during the intragastric infusion of\n ND<\/jats:styled-content>\n until maximal satiation.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Mirtazapine significantly increased the bodyweight of subjects (67.8\u00b13.7 to 69.1\u00b13.7\u00a0kg;\n P<\/jats:italic>\n =.01). Barostat results showed no effect on gastric compliance, sensitivity, and\n GA<\/jats:styled-content>\n . Nutrient tolerance was not affected after treatment (1170\u00b1129.4 vs 1104\u00b1133.6\u00a0kcal;\n P<\/jats:italic>\n =.4), and mirtazapine was associated with lower symptom ratings. The\n IGP<\/jats:styled-content>\n drop during meal ingestion was significantly suppressed (area under the curve: \u221243.3\u00b14.5\u00a0mm Hg vs \u221228.9\u00b13.1\u00a0mm Hg;\n P<\/jats:italic>\n =.005).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n In\n HV<\/jats:styled-content>\n s, the occurrence of weight gain and decreased meal\u2010induced symptoms in spite of a suppressed meal\u2010induced\n IGP<\/jats:styled-content>\n drop, point towards a central mode of action. Mirtazapine does not display changes in gastric sensorimotor function that could explain its beneficial effects on symptoms and nutrient tolerance in\n FD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.13146","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T01:06:57Z","timestamp":1499735217000},"source":"Crossref","is-referenced-by-count":34,"title":["The effect of mirtazapine on gastric accommodation, gastric sensitivity to distention, and nutrient tolerance in healthy subjects"],"prefix":"10.1111","volume":"29","author":[{"given":"F.","family":"Carbone","sequence":"first","affiliation":[{"name":"TARGID and Department of Gastroenterology, Neurogastroenterology & Motility University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"TARGID and Department of Gastroenterology, Neurogastroenterology & Motility University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"TARGID and Department of Gastroenterology, Neurogastroenterology & Motility University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12585"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01262.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.14"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-43"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.77244"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01935.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.158162"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357854"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.085365"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27180"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000511"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.11"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.06.036"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03849.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01469.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01671.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2001.tb00198.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00224-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-007-0670-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2007.01778.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0313"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.08.065"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01526.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.47.5.440"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-38"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00130.2013"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.81.392"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.09.043"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.9.1271"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.468"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.101"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.02.2009.1579"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i21.6671"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03520.x"},{"key":"e_1_2_9_39_1","first-page":"67","article-title":"[Effects of mirtazapine in patients with chronic tension\u2010type headache. 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