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This study assessed the effects of PNHFD<\/jats:styled-content> on inhibitory synaptic inputs to DMV<\/jats:styled-content> neurons and the vagally dependent control of gastric tone and motility.<\/jats:p><\/jats:sec>Methods<\/jats:title>Whole\u2010cell patch clamp recordings were made from DMV<\/jats:styled-content> neurons in thin brainstem slices from Sprague\u2010Dawley rats fed either a control diet or HFD<\/jats:styled-content> (14 or 60%\u00a0kcal from fat, respectively) from embryonic day 13 onwards; gastric tone and motility were recorded in in vivo anesthetized rats.<\/jats:p><\/jats:sec>Key Results<\/jats:title>The non\u2010selective GABAA<\/jats:sub><\/jats:styled-content> antagonist, BIC<\/jats:styled-content> (10\u00a0\u03bcmol\u00a0L\u20131<\/jats:sup>), induced comparable inward currents in PNHFD<\/jats:styled-content> and control DMV<\/jats:styled-content> neurons, but a larger current in PNHFD<\/jats:styled-content> neurons at higher concentrations (50\u00a0\u03bcmol\u00a0L\u20131<\/jats:sup>). Differences were not apparent in neuronal responses to the phasic GABAA<\/jats:sub><\/jats:styled-content> antagonist, gabazine (GBZ<\/jats:styled-content>), the extrasynaptic GABAA<\/jats:sub><\/jats:styled-content> agonist, THIP<\/jats:styled-content>, the GABA<\/jats:styled-content> transport blocker, nipecotic acid, or the gliotoxin, fluoroacetate, suggesting that PNHFD<\/jats:styled-content> altered inhibitory transmission but not GABAA<\/jats:sub><\/jats:styled-content> receptor density or function, GABA<\/jats:styled-content> uptake or glial modulation of synaptic strength. Similarly, the increase in gastric motility and tone following brainstem microinjection of low doses of BIC<\/jats:styled-content> (1\u201010\u00a0pmoles) and GBZ<\/jats:styled-content> (0.01\u20100.1\u00a0pmoles) were unchanged in PNHFD<\/jats:styled-content> rats while higher doses of BIC<\/jats:styled-content> (25\u00a0pmoles) induced a significantly larger increase in gastric tone compared to control.<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>These studies suggest that exposure to PNHFD<\/jats:styled-content> increases the tonic inhibition of DMV<\/jats:styled-content> neurons, possibly contributing to dysregulated vagal control of gastric functions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13150","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T09:57:04Z","timestamp":1501581424000},"source":"Crossref","is-referenced-by-count":23,"title":["Perinatal high fat diet increases inhibition of dorsal motor nucleus of the vagus neurons regulating gastric functions"],"prefix":"10.1111","volume":"30","author":[{"given":"C. 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