{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:05:05Z","timestamp":1790744705484,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Complex gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) motility disorders such as chronic intestinal pseudo\u2010obstruction (<jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content>) or Hirschsprung's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) are challenging to diagnose and treat appropriately. Thorough assessment of patient history, radiographic exams, endoscopy, and motility measurements aid in diagnostic workup, yet underlying histology is the cornerstone to enable a more distinct diagnosis of neuromuscular <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> disorders. Traditionally, surgical procedures have been performed to obtain specimen suitable for accurate histologic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed endoscopic full\u2010thickness resection (<jats:styled-content style=\"fixed-case\">eFTR<\/jats:styled-content>) using a full\u2010thickness\u2010resection device (<jats:styled-content style=\"fixed-case\">FTRD<\/jats:styled-content>) under moderate propofol sedation in four patients with suspected severe neuromuscular gut disorders including <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The mean age of the four patients was 43\u00a0y (range 19\u201056\u00a0y). Technical and histological success providing large colonic full\u2010thickness tissue samples of excellent quality was achieved in all four patients (success rate 100%). The mean procedure time was 12\u00a0min (range 5\u201020\u00a0min). The mean diameter of the resected specimen was 21\u00a0mm (range 20\u201022\u00a0mm). No adverse events connected to the procedure itself occurred. Histology ranged from aganglionosis such as Hirschsprung's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) to hypoganglionosis and eosinophilic leiomyositis combined with lymphocytic ganglionitis in a third patient. Histology was unspecific in one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EFTR<\/jats:styled-content> allows safe and minimal invasive harvesting of ample full\u2010thickness tissue samples for accurate histological analysis in patients with suspicion of neuromuscular gut disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13153","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T06:14:44Z","timestamp":1499321684000},"source":"Crossref","is-referenced-by-count":33,"title":["Diagnostic use of endoscopic full\u2010thickness wall resection (<scp>eFTR<\/scp>)\u2014a novel minimally invasive technique for colonic tissue sampling in patients with severe gastrointestinal motility disorders"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-547X","authenticated-orcid":false,"given":"P. V.","family":"Valli","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pohl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fried","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Caduff","sequence":"additional","affiliation":[{"name":"Institute of Surgical Pathology and Molecular Pathology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bauerfeind","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.200444"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90121-E"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01099.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/13645706.2011.582119"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1391781"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.053"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01657.x"},{"issue":"1575","key":"e_1_2_10_9_1","first-page":"e8","article-title":"Cellular changes in diabetic and idiopathic gastroparesis","volume":"140","author":"Grover M","year":"2011","journal-title":"Gastroenterology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0527-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.192"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200107000-00009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.11.048"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.12.037"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.10.017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.03.010"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:47:36Z","timestamp":1695538056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,6]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/nmo.13153"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13153","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,6]]},"article-number":"e13153"}}