{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:41Z","timestamp":1760189561695,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01 DK079902"],"award-info":[{"award-number":["R01 DK079902"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The Chicago Classification v3.0 proposed extending the distal contractile integral (DCI<\/jats:styled-content>) measurement domain to include the lower esophageal sphincter (LES<\/jats:styled-content>) to enhance the detection of esophageal hypercontractility. However, normative and clinical data for this approach are unreported. We aimed to describe the application of an extended DCI<\/jats:styled-content> measurement in asymptomatic controls and patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>High\u2010resolution manometry (HRM<\/jats:styled-content>) of 65 asymptomatic controls and 72 patients with normal motility were evaluated retrospectively. Dysphagia and chest pain symptoms were assessed using the brief esophageal dysphagia questionnaire (BEDQ<\/jats:styled-content>); \u226510 was considered abnormal. HRM<\/jats:styled-content> studies of 10 supine swallows were evaluated via the standard DCI<\/jats:styled-content> and an extended DCI<\/jats:styled-content> measurement domain (DCI<\/jats:styled-content>+) to include the lower esophageal sphincter (LES<\/jats:styled-content>) during and after the peristaltic wave. The DCI<\/jats:styled-content>\u2010increment was calculated as the DCI<\/jats:styled-content>+ minus DCI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Among controls, the median (5\u201095th percentile) DCI<\/jats:styled-content>+ was 1915 (1359\u20106921)\u00a0mm Hg\/cm\/s and DCI<\/jats:styled-content>\u2010increment was 534 (126\u20101488)\u00a0mm Hg\/cm\/s. Two patients (3%) had \u22652 swallows with DCI<\/jats:styled-content>+ >8000\u00a0mm Hg\/cm\/s and seven (10%) patients had at least one swallow with DCI<\/jats:styled-content>+ >8000\u00a0mm Hg\/cm\/s, ie, had potential motility reclassification by application of DCI<\/jats:styled-content>+. Seven of these nine patients (78%) were evaluated for dysphagia or chest pain, but only 3\/9 (33%) had an abnormal BEDQ<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>Extension of the DCI<\/jats:styled-content> measurement domain may aid quantifying hypercontractility that involves the LES<\/jats:styled-content>. However, adjusting management strategies based on reclassification of patients with otherwise normal motility should be cautiously considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13156","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:31:06Z","timestamp":1500625866000},"source":"Crossref","is-referenced-by-count":7,"title":["High\u2010resolution manometry assessment of the lower esophageal sphincter after\u2010contraction: Normative values and clinical correlation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"D. A.","family":"Carlson","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Kahrilas","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tye","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Listernick","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology the First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Bul","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"},{"name":"Department of Medicine University of Illinois College of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"G677","article-title":"Topography of the esophageal peristaltic pressure wave","volume":"261","author":"Clouse RE","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.145"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01532.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ajg.2011.313","article-title":"Phenotypes and clinical context of hypercontractility in high\u2010resolution esophageal pressure topography (EPT)","volume":"107","author":"Roman S","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1001\/jama.1969.03160060062006","article-title":"Gastroesophageal hypercontracting sphincter. Manometric and clinical characteristics","volume":"208","author":"Garrett JM","year":"1969","journal-title":"JAMA"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01834.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12889"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31815ea291"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.10.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12975"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:45:23Z","timestamp":1695537923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/nmo.13156"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13156","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2017,7,21]]},"article-number":"e13156"}}