{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:16:41Z","timestamp":1785370601374,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15DK097460\u201001"],"award-info":[{"award-number":["R15DK097460\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56\u2010DK080787\u201006"],"award-info":[{"award-number":["R56\u2010DK080787\u201006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK097518"],"award-info":[{"award-number":["R01DK097518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abdominal pain is associated with many gastrointestinal dysfunctions, such as irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>), functional dyspepsia, and inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>). Visceral hypersensitivity is a key reason for development of abdominal pain that presents in these gastrointestinal disorders\/diseases. The pathogenesis of visceral hypersensitivity is complex and still far from being fully understood. In animal studies, visceral hypersensitivity has been linked to several early\u2010life adverse (<jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content>) events. In humans, <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>, functional\u00a0dyspepsia, and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> can have adult onset, though the adverse events that lead to visceral hypersensitivity are largely uncharacterized. In this issue of the journal, Aguirre et\u00a0al. report the interesting finding that epigenetics underlies the effects of <jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content> events on visceral hypersensitivity. This mini\u2010review examines models of <jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content> events leading to visceral hypersensitivity and the potential role of epigenetics, as reported by Aguirre et\u00a0al. and others.<\/jats:p>","DOI":"10.1111\/nmo.13170","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:00:15Z","timestamp":1502092815000},"source":"Crossref","is-referenced-by-count":45,"title":["Early\u2010life adversity, epigenetics, and visceral hypersensitivity"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biology College of Science and Health University of Wisconsin\u2010La Crosse  La Crosse WI 54601 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SI.","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"The Osher Center for Integrative Medicine University of California San Francisco  San Francisco CA 94143 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-0517","authenticated-orcid":false,"given":"A.","family":"Bhargava","sequence":"additional","affiliation":[{"name":"The Osher Center for Integrative Medicine University of California San Francisco  San Francisco CA 94143 USA"},{"name":"Department of Ob\u2010Gyn University of California San Francisco  San Francisco CA 94143 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463713479229"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.12.018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01722.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13081"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.19576"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.12.035"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.093"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00949.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019498"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12675"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.026"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1350-1925.2003.00451.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00498.2004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12202"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(96)00153-1"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000292"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12326"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916660722"},{"issue":"148","key":"e_1_2_12_20_1","first-page":"e147","article-title":"Epigenetic regulation of genes that modulate chronic stress\u2010induced visceral pain in the peripheral nervous system","volume":"148","author":"Hong S","year":"2015","journal-title":"Gastroenterology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.09.016"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.122"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1787609"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2010"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)00849-3"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.05.011"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12725"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13787"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.09.007"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.07.054"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO;2-G"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1177"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.01.006"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12103"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00067.2016"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00342.2015"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00445.2015"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.020"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03961.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.01015.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:39:59Z","timestamp":1695508799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/nmo.13170"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13170","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]},"article-number":"e13170"}}