{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:13:12Z","timestamp":1786605192984,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Research grant"],"award-info":[{"award-number":["Research grant"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While these findings suggest that gastrointestinal bitter taste receptors could be new targets to modulate gastrointestinal motility and hormone release, they need confirmation with other bitter receptor agonists. The primary aim was to evaluate the effect of intragastric administration of the bitter tastant quinine\u2010hydrochloride (<jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l) on motilin and ghrelin plasma levels. Secondly, we studied the effect on interdigestive motility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten healthy female volunteers were recruited (33\u00b14\u00a0y; 22\u00b10.5\u00a0kg\/m\u00b2). Placebo or <jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l (10\u00a0\u03bcmol\/kg) was administered intragastrically through a nasogastric feeding tube after an overnight fast in a single\u2010blind randomized fashion. Administration started 20\u00a0min after the first phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> of the migrating motor complex. The measurement continued for another 2\u00a0h after the administration. Blood samples were collected every 10\u00a0min with the baseline sample taken 10\u00a0min prior to administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The increase in plasma levels of motilin (administration; <jats:italic>P<\/jats:italic>=.04) and total ghrelin (administration; <jats:italic>P<\/jats:italic>=.02) was significantly lower after <jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l. The fluctuation of octanoylated ghrelin was reduced after <jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l (time by administration; <jats:italic>P<\/jats:italic>=.03). Duodenal motility did not differ. The fluctuation of antral activity differed over time between placebo and <jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l (time by administration; <jats:italic>P<\/jats:italic>=.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l suppresses the increase of both motilin and ghrelin plasma levels. Moreover, <jats:styled-content style=\"fixed-case\">QHC<\/jats:styled-content>l reduced the fluctuation of antral motility. These findings confirm the potential of bitter taste receptors as targets for modifying interdigestive motility in man.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13171","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T10:43:48Z","timestamp":1501843428000},"source":"Crossref","is-referenced-by-count":45,"title":["Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers"],"prefix":"10.1111","volume":"30","author":[{"given":"E.","family":"Deloose","sequence":"first","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Corsetti","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven  Leuven Belgium"},{"name":"National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Van Oudenhove","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Depoortere","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"The Control of Hunger in Health and Disease","author":"Carlson A","year":"1916"},{"issue":"13","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1073\/pnas.93.13.6631","article-title":"Taste receptor\u2010like cells in the rat gut identified by expression of alpha\u2010gustducin","volume":"93","author":"Hofer D","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90514.2008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15985"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00344.2011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011508108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200509000-00012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.138297"},{"key":"e_1_2_10_10_1","unstructured":"RotondoA DelooseE TothJ DepoortereI TackJ.Activation of gastric bitter taste receptor by quinine hydrochloride effects on intragastric pressure profiles and nutrient tolerance in healthy volunteers. 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