{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:14:56Z","timestamp":1792815296752,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004482","name":"Kuwait University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Feeding triggers inter\u2010related gastrointestinal (GI<\/jats:styled-content>) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI<\/jats:styled-content> advances allow pan\u2010intestinal, non\u2010invasive assessment of motility in the undisturbed gut.<\/jats:p>This study aimed to develop a methodology to assess pan\u2010intestinal motility and transit in a single session using MRI<\/jats:styled-content> and compare imaging findings to GI<\/jats:styled-content> peptide responses to a test meal and symptoms in a healthy volunteer cohort.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifteen healthy volunteers (29.3\u00b12.7\u00a0years and BMI<\/jats:styled-content> 20.1\u00b11.2\u00a0kg\u00a0m\u22122<\/jats:sup>) underwent baseline and postprandial MRI<\/jats:styled-content> scans, symptom questionnaires, and blood sampling (for subsequent GI<\/jats:styled-content> peptide analysis, Glucagon\u2010like peptide\u20101 [GLP<\/jats:styled-content>\u20101], Polypeptide YY<\/jats:styled-content> [PYY<\/jats:styled-content>], Cholecystokinin [CCK<\/jats:styled-content>]) at intervals for 270\u00a0minutes following a 400\u00a0g soup meal (204\u00a0kcal, Heinz, UK<\/jats:styled-content>). Gastric volume, gall bladder volume, small bowel water content, small bowel motility, and whole gut transit were measured from the MRI<\/jats:styled-content> scans.<\/jats:p><\/jats:sec>Key Results<\/jats:title>(mean\u00b1SEM<\/jats:styled-content>) Small bowel motility index increased from fasting 39\u00b13 arbitrary units (a.u.) to a maximum of 87\u00b17\u00a0a.u. immediately after feeding. PYY<\/jats:styled-content> increased from fasting 98\u00b110\u00a0pg\u00a0mL\u22121<\/jats:sup> to 149\u00b114\u00a0pg\u00a0mL\u22121<\/jats:sup> at 30\u00a0minutes and GLP<\/jats:styled-content>\u20101 from fasting 15\u00b13\u00a0\u03bcg\u00a0mL\u22121<\/jats:sup> to 22\u00b14\u00a0\u03bcg\u00a0mL\u22121<\/jats:sup>. CCK<\/jats:styled-content> increased from fasting 0.40\u00b10.06\u00a0pmol\u00a0mL\u22121<\/jats:sup> to 0.94\u00b10.1\u00a0pmol\u00a0mL\u22121<\/jats:sup>. Gastric volumes declined with a T1\/2<\/jats:sub> of 46\u00b15\u00a0minute and the gallbladder contracted from a fasting volume of 19\u00b12\u00a0mL\u22121<\/jats:sup> to 12\u00b12\u00a0mL\u22121<\/jats:sup>. Small bowel water content increased from 39\u00b12\u00a0mL\u22121<\/jats:sup> to 51\u00b12\u00a0mL\u22121<\/jats:sup> postprandial. Fullness VAS<\/jats:styled-content> score increased from 9\u00b15\u00a0mm to 41\u00b16\u00a0mm at 30\u00a0minutes postprandial.<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>The test meal challenge was effective in inducing a change in MRI<\/jats:styled-content> motility end\u2010points which will improve understanding of the pathophysiological postprandial GI<\/jats:styled-content> response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13182","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T12:12:50Z","timestamp":1504181570000},"source":"Crossref","is-referenced-by-count":33,"title":["MRI<\/scp> assessment of the postprandial gastrointestinal motility and peptide response in healthy humans"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-5047","authenticated-orcid":false,"given":"A.","family":"Khalaf","sequence":"first","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"},{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Hoad","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"},{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Menys","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging Division of Medicine UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nowak","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging Division of Medicine UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Paparo","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"},{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lingaya","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Falcone","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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