{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:17:29Z","timestamp":1787588249956,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001722","name":"Koninklijke Nederlandse Akademie van Wetenschappen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the long\u2010term efficacy of sacral nerve stimulation (<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>) in children with constipation and describe patient benefit and parent satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a prospective patient registry, we identified patients &lt;21\u00a0years old with constipation treated with <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> for &gt;2\u00a0years. We compared symptoms, medical treatment, PedsQL Gastrointestinal Symptom Scale (<jats:styled-content style=\"fixed-case\">GSS<\/jats:styled-content>), Fecal Incontinence Quality of Life Scale (<jats:styled-content style=\"fixed-case\">FIQL<\/jats:styled-content>), and Fecal Incontinence Severity Index (<jats:styled-content style=\"fixed-case\">FISI<\/jats:styled-content>) before <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> and at follow\u2010up. We contacted parents to administer the Glasgow Children's Benefit Inventory (<jats:styled-content style=\"fixed-case\">GCBI<\/jats:styled-content>) and a parent satisfaction questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>We included 25 children (52% male, median age 10\u00a0years): 16 had functional constipation, six anorectal malformation, two tethered spinal cord, and one Hirschsprung's disease. Defecation frequency did not change after <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> but patients reporting fecal incontinence decreased from 72% to 20% (<jats:italic>P<\/jats:italic>&lt;.01) and urinary incontinence decreased from 56% to 28% (<jats:italic>P<\/jats:italic>=.04). Patients using laxatives decreased from 64% to 44% (ns) and patients using antegrade enemas decreased from 48% to 20% (<jats:italic>P<\/jats:italic>=.03). GSS, most <jats:styled-content style=\"fixed-case\">FIQL<\/jats:styled-content> domains, and <jats:styled-content style=\"fixed-case\">FISI<\/jats:styled-content> were improved at follow\u2010up. Six (24%) patients had complications requiring further surgery. Of the 16 parents contacted, 15 (94%) parents indicated positive health\u2010related benefit and all would recommend <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> to other families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Sacral nerve stimulation is a promising and durable treatment for children with refractory constipation, and appears particularly effective in decreasing fecal incontinence. Although a quarter of patients experienced complications requiring additional surgery, nearly all parents reported health\u2010related benefit. Future studies to identify predictors of treatment response and complications are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13184","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T03:52:43Z","timestamp":1502423563000},"source":"Crossref","is-referenced-by-count":60,"title":["Sacral nerve stimulation for constipation and fecal incontinence in children: Long\u2010term outcomes, patient benefit, and parent satisfaction"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-3353","authenticated-orcid":false,"given":"P. L.","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J. N.","family":"Koppen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital\/Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. K.","family":"Orsagh\u2010Yentis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Leonhart","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Ambeba","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. J.","family":"Deans","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Minneci","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Teich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Levine Children's Hospital  Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Diefenbach","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Alpert","sequence":"additional","affiliation":[{"name":"Division of Urology Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital\/Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Yacob","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.12.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00888-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000266"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001236"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001191"},{"key":"e_1_2_10_7_1","first-page":"CD004464","article-title":"Sacral nerve stimulation for faecal incontinence and constipation in adults","volume":"8","author":"Thaha MA","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.101"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10326"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182405c61"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.03.043"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2604-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200612000-00001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237236"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236199"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411301208"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.06.090"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.11.029"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001110"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2007.01578.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a3c133"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12485"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.11.003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i2.294"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"13","article-title":"Sacral nerve stimulation for treatment of constipation in children: long\u2010term outcomes, patient benefit, and parent satisfaction","volume":"28","author":"Lu PL","year":"2016","journal-title":"Neurogastroenterol Motil"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:07:07Z","timestamp":1695888427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,10]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/nmo.13184"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13184","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,10]]},"article-number":"e13184"}}