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Reciprocal baroreflex mechanisms of blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) control were found to impact differently on pain regulation, and thus their asymmetry was hypothesized to also connect to chronic pain duration and severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010eight female patients with irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) and 27 healthy women were assessed for<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>severity and chronicity, negative affect, and various measures of resting autonomic function including<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, heart rate and its variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>), baroreceptor\u2010sensitivity to activations and inhibitions, gains of brady\u2010 and tachy\u2010cardiac baro\u2010responses, gains of<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>falls\/rises, and<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>start points for these spontaneous baroreflexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>directly and indirectly (through increased negative affect) was associated with asymmetry between baroreceptor activations\/inhibitions compared to symmetrical baroreflex reciprocity in the healthy women. In the<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>group, independently of specific<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>symptoms, pain chronicity was associated with (i) decreased<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>falls coupled with either (a) decreased tachycardia associated with lower disease severity (earlier \u201cpain resilience\u201d mechanism), or (b) decreased bradycardia associated with higher disease severity (later \u201cpain decompensation\u201d mechanism), or (ii) increased<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>start point for baroreceptor activations coupled with either (a)<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>increase (delayed \u201cpain adaptation\u201d mechanism) or (b) affect\u2010related<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>decrease (delayed \u201cpain aggravation\u201d mechanism).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>We anticipate the findings to be a starting point for validating these autonomic metrics of pain suffering and pain coping mechanisms in other chronic pain syndromes to suggest them as biomarkers of its severity and duration for profiling and correct management of chronic pain patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13186","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T08:06:46Z","timestamp":1503389206000},"source":"Crossref","is-referenced-by-count":18,"title":["Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-0572","authenticated-orcid":false,"given":"D. 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