{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:06:13Z","timestamp":1791515173263,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007658","name":"Crohn's and Colitis Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Increases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta\u2010analysis of case\u2013<\/jats:bold>control studies that compared immune cell counts in colonic biopsies of IBS<\/jats:styled-content> patients and controls.<\/jats:p><\/jats:sec>Methods<\/jats:title>PubMed and Embase were searched in February 2017. Results were pooled using standardized mean difference (SMD<\/jats:styled-content>) and were considered significant when zero was not within the 95% confidence interval (CI<\/jats:styled-content>). Heterogeneity was assessed based on I<\/jats:italic>2<\/jats:sup> statistics where I<\/jats:italic>2<\/jats:sup>\u00a0\u2264\u00a050% and I<\/jats:italic>2<\/jats:sup>\u00a0>\u00a050% indicated fixed and random effect models, respectively.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Twenty\u2010two studies on 706 IBS<\/jats:styled-content> patients and 401 controls were included. Mast cells were increased in the rectosigmoid (SMD<\/jats:styled-content>: 0.38 [95% CI<\/jats:styled-content>: 0.06\u20100.71]; P<\/jats:italic>\u00a0=\u00a0.02) and descending colon (SMD<\/jats:styled-content>: 1.69 [95% CI<\/jats:styled-content>: 0.65\u20102.73]; P\u00a0<\/jats:italic>=\u00a0.001) of IBS<\/jats:styled-content> patients. Increased mast cells were observed in both constipation (IBS<\/jats:styled-content>\u2010C) and diarrhea predominant IBS<\/jats:styled-content> (IBS<\/jats:styled-content>\u2010D). CD<\/jats:styled-content>3+<\/jats:sup> T cells were increased in the rectosigmoid (SMD<\/jats:styled-content>: 0.53 [95% CI<\/jats:styled-content>: 0.21\u20100.85]; P<\/jats:italic>\u00a0=\u00a0.001) and the descending colon of the IBS<\/jats:styled-content> patients (SMD<\/jats:styled-content>: 0.79, 95% CI<\/jats:styled-content> [0.28\u20101.30]; P\u00a0<\/jats:italic>=\u00a0.002). This was possibly in relation to higher CD<\/jats:styled-content>4+<\/jats:sup> T cells in IBS<\/jats:styled-content> (SMD<\/jats:styled-content>: 0.33 [95% CI<\/jats:styled-content>: 0.01\u20100.65]; P<\/jats:italic>\u00a0=\u00a0.04) as there were no differences in CD<\/jats:styled-content>8+<\/jats:sup> T cells.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Mast cells and CD<\/jats:styled-content>3+<\/jats:sup> T cells are increased in colonic biopsies of patients with IBS<\/jats:styled-content> vs non\u2010inflamed controls. These changes are segmental and sometimes IBS<\/jats:styled-content>\u2010subtype dependent. The diagnostic value of the quantification of colonic mucosal cells in IBS<\/jats:styled-content> requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13192","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T15:28:07Z","timestamp":1504020487000},"source":"Crossref","is-referenced-by-count":162,"title":["Colonic immune cells in irritable bowel syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-4715","authenticated-orcid":false,"given":"M.","family":"Bashashati","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Texas Tech University Health Sciences Center\/Paul L. Foster School of Medicine El Paso TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moossavi","sequence":"additional","affiliation":[{"name":"Digestive Oncology Research Center Digestive Disease Research Institute Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Medical Microbiology University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-2936","authenticated-orcid":false,"given":"C.","family":"Cremon","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Centre for Applied Biomedical Research University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Centre for Applied Biomedical Research University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moraveji","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Texas Tech University Health Sciences Center\/Paul L. 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A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Centre for Nutritional and Gastrointestinal Diseases Department of Medicine University of Adelaide and South Australian Health Medical Health Research Institute Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-1958","authenticated-orcid":false,"given":"Z. X.","family":"Bian","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Hong Kong Baptist University Kowloon Tong, Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Co\u00ebffier","sequence":"additional","affiliation":[{"name":"Normandie Univ INSERM unit 1073 \u201cNutrition, inflammation and brain\u2010gut axis\u201d Institute for Research and Innovation in Biomedicine Rouen Medical University and Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chang","sequence":"additional","affiliation":[{"name":"G Oppenheimer Center of Neurobiology of Stress and Resilience David Geffen School of Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ohman","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Clinical Nutrition and Microbiology and Immunology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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