{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:52:04Z","timestamp":1779310324887,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent reports show increasing incidence of achalasia in some populations. The aim of this study was to estimate incidence, prevalence, and healthcare costs of achalasia in a large cohort in The Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the largest Dutch healthcare insurance company (\u00b14.4\u00a0million insured). Adult achalasia patients were identified between 2006 and 2014 when having an achalasia diagnosis code registered. A total of 907 achalasia patients were identified and included in our database, along with 9068 control patients (non\u2010achalasia patients), matched by age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The mean incidence over the 9\u2010year period was 2.2 per 100\u00a0000 persons and the mean prevalence was 15.3 per 100\u00a0000 persons. Mean age of achalasia patients was 54 (range 18\u201098)\u00a0years. Male to female ratio was 1:1. Socio\u2010economic status distribution was similar in achalasia patients and controls. Prior to the diagnosis, 74% of achalasia patients received proton pump inhibitors and 26% received anti\u2010emetic medication. The first year after diagnosis median total direct medical costs of achalasia patients were \u20ac2283 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 969\u20103044) per year. Patients above the 90th percentile of \u20ac4717 were significantly older than other patients below the 90th percentile (mean age 63 vs 57); <jats:italic>P\u00a0<\/jats:italic>=\u00a0.005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>In this large study that used a database comprising about 25% of all inhabitants of The Netherlands, it is confirmed that achalasia affects individuals of both genders and all ages. The costs associated with diagnosis and treatment of new cases of achalasia increase with increasing age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13195","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T11:33:59Z","timestamp":1503574439000},"source":"Crossref","is-referenced-by-count":38,"title":["Incidence and costs of achalasia in The Netherlands"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-3869","authenticated-orcid":false,"given":"F. B.","family":"van Hoeij","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A.","family":"Ponds","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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