{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:04Z","timestamp":1790744524896,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF 2016\u201076648\u2010R"],"award-info":[{"award-number":["SAF 2016\u201076648\u2010R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GGP15171"],"award-info":[{"award-number":["GGP15171"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004740","name":"Fondazione del Monte di Bologna e Ravenna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intestinal manometry is the current standard for direct evaluation of small bowel dysmotility. Patients with abnormal motility can either be diagnosed of pseudo\u2010obstruction when there are radiological findings mimicking mechanical intestinal obstruction or of enteric dysmotility when these findings are absent. The aim of the present study was to prospectively compare small bowel manometric abnormalities with histopathological findings in intestinal full\u2010thickness biopsies in patients with severe dysmotility disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 38 patients with intestinal manometry and a subsequent full\u2010thickness intestinal biopsy. Manometric recordings were read by 4 investigators and a diagnostic consensus was obtained in 35 patients. Histopathological analysis, including specific immunohistochemical techniques of small bowel biopsies was performed and compared to manometric readings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Patients with abnormal intestinal manometry had abnormal histopathological findings in 73% of cases. However, manometric patterns did not match with the specific neuromuscular abnormalities. Among patients with a neuropathic manometry pattern and abnormal histopathology, only 23% had an enteric neuropathy, whereas 62% had neuromuscular inflammation, and 15% an enteric myopathy. On the other hand, patients with a myopathic manometry pattern all had abnormal histopathology, however, none of them with signs of enteric myopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>Small bowel dysmotility detected by intestinal manometry is often associated with abnormal neuromuscular findings in full\u2010thickness biopsies. However, there is no correlation between the specific manometric patterns and the histopathological findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13219","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T08:08:40Z","timestamp":1506067720000},"source":"Crossref","is-referenced-by-count":38,"title":["Comparison between small bowel manometric patterns and full\u2010thickness biopsy histopathology in severe intestinal dysmotility"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-1492","authenticated-orcid":false,"given":"C.","family":"Malagelada","sequence":"first","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. B.","family":"Karunaratne","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Sciences and Digestive System Centro di Ricerca Biomedica Applicata (C.R.B.A.) University of Bologna St. Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Accarino","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"Cogliandro","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Sciences and Digestive System Centro di Ricerca Biomedica Applicata (C.R.B.A.) University of Bologna St. Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Landolfi","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gori","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Sciences and Digestive System Centro di Ricerca Biomedica Applicata (C.R.B.A.) University of Bologna St. Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Boschetti","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Sciences and Digestive System Centro di Ricerca Biomedica Applicata (C.R.B.A.) University of Bologna St. Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Malagelada","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Stanghellini","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Sciences and Digestive System Centro di Ricerca Biomedica Applicata (C.R.B.A.) University of Bologna St. Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-960X","authenticated-orcid":false,"given":"F.","family":"Azpiroz","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-5873","authenticated-orcid":false,"given":"R.","family":"De Giorgio","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Sciences and Digestive System Centro di Ricerca Biomedica Applicata (C.R.B.A.) University of Bologna St. Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12726"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01612.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.084"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01823.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00193.2015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00902.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.17.s1.7.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902839642"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01783.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.148296"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043968"},{"key":"e_1_2_9_13_1","article-title":"Chronic intestinal pseudo\u2010obstruction in children and adults: diagnosis and therapeutic options","volume":"29","author":"Di Nardo G","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01230.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03265.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(02)04359-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.037275"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00675-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.4.468"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0527-y"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.200444"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1322"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.024"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37059"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.9.1236"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018874602790"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04684.x"}],"container-title":["Neurogastroenterology &amp; 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