{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:20:41Z","timestamp":1789050041851,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Integrated relaxation pressure (IRP<\/jats:styled-content>) is a key metric for diagnosing esophagogastric junction outflow obstruction (EGJOO<\/jats:styled-content>). However, its normal value might be different according to the manufacturer of high\u2010resolution manometry (HRM<\/jats:styled-content>). This study aimed to investigate optimal value of IRP<\/jats:styled-content> for diagnosing EGJOO<\/jats:styled-content> in Sandhill HRM<\/jats:styled-content> and to find clinicomanometric variables to segregate clinically relevant EGJOO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed 262 consecutive subjects who underwent HRM<\/jats:styled-content> between June 2011 and December 2016 showing elevated median IRP<\/jats:styled-content> (>\u00a015\u00a0mm\u00a0Hg) but did not satisfy criteria for achalasia. Clinically relevant subjects were defined as follows: (i) subsequent HRM<\/jats:styled-content> met achalasia criteria during follow\u2010up (early achalasia); (ii) Eckardt score was decreased at least two points without exceeding a score of 3 after pneumatic dilatation (variant achalasia); and (iii) significant passage disturbance on esophagogram without structural abnormality (possible achalasia).<\/jats:p><\/jats:sec>Key Results<\/jats:title>Seven subjects were clinically relevant, including two subjects with early achalasia, four subjects with variant achalasia, and one subject with possible achalasia. All clinically relevant subjects had IRP<\/jats:styled-content> 20\u00a0mm\u00a0Hg or above. Among subjects (n\u00a0=\u00a0122) with IRP<\/jats:styled-content> 20\u00a0mm\u00a0Hg or more, clinically relevant group (n\u00a0=\u00a07) had significantly higher rate of dysphagia (100% vs 24.3%, P<\/jats:italic>\u00a0<\u00a0.001) and compartmentalized pressurization (85.7% vs 21.7%, P<\/jats:italic>\u00a0=\u00a0.001) compared to clinically non\u2010relevant group (n\u00a0=\u00a0115).<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Our results suggest that IRP<\/jats:styled-content> of 20\u00a0mm\u00a0Hg or higher could segregate clinically relevant subjects showing EGJOO<\/jats:styled-content> in Sandhill HRM<\/jats:styled-content>. Additionally, if subjects have both dysphagia and compartmentalized pressurization, careful follow\u2010up is essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13221","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T12:06:50Z","timestamp":1507637210000},"source":"Crossref","is-referenced-by-count":35,"title":["Clinicomanometric factors associated with clinically relevant esophagogastric junction outflow obstruction from the Sandhill high\u2010resolution manometry system"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-7846","authenticated-orcid":false,"given":"B. G.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7471-1305","authenticated-orcid":false,"given":"Y. W.","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u2010H.","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010L.","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01829.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12708"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12625"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13061"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12814"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0975-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12501"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01273.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.68"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12320"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12285"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12167"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12500"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.02.022"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01830.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12029"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12446"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12027"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12314"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00252.2007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01682.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01952.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16041"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T15:59:31Z","timestamp":1694793571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/nmo.13221"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13221","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]},"article-number":"e13221"}}