{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:51:00Z","timestamp":1791838260886,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK092217"],"award-info":[{"award-number":["R01 DK092217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased esophagogastric junction (<jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>) distensibility is thought to contribute to gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>). Using the functional lumen imaging probe (<jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>), we aimed to assess the esophageal response to distension among patients undergoing esophageal <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>25 patients (ages 22\u201073; 13 females) who underwent ambulatory wireless esophageal <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> testing while off proton\u2010pump inhibitors were evaluated with <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content> during sedated upper endoscopy. Esophageal reflux was quantified by total percent acid exposure time (<jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>; &lt;6% was considered normal). <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content> studies were analyzed using a customized program generate <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content> topography plots to identify esophageal contractility patterns and to calculate the <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\u2010distensibility index (<jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content>). Reflux symptoms were assessed with the <jats:styled-content style=\"fixed-case\">GERDQ<\/jats:styled-content>. Values reflect median (interquartile range).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all patients, the <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> was 7.2% (3.7\u201011.1) and <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content> was 4.2 (2.5\u20107.6)\u00a0mm<jats:sup>2<\/jats:sup>\/mm\u00a0Hg. Repetitive antegrade contractions (<jats:styled-content style=\"fixed-case\">RAC<\/jats:styled-content>s) were induced in 19\/25 (76%) of patients; <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> was lower among patients with (6.1%, 3\u20107.8) than without (14.9, 8.5\u201022.3) <jats:styled-content style=\"fixed-case\">RAC<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.009). Correlation was weak and insignificant between <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GERDQ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">GERDQ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content>. Patients with abnormal <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> (n\u00a0=\u00a016) and normal <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> (n\u00a0=\u00a09) had similar <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content>, 4.6\u00a0mm<jats:sup>2<\/jats:sup>\/mm\u00a0Hg (2.9\u20109.2) vs 3.2 (2.2\u20105.1), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.207 and <jats:styled-content style=\"fixed-case\">GERDQ<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a0.138.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal esophageal acid exposure was associated with an impaired contractile response to volume distention of the esophagus. This supports that acid exposure is dependent on acid clearance mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13240","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T04:57:02Z","timestamp":1509685022000},"source":"Crossref","is-referenced-by-count":48,"title":["The relationship between esophageal acid exposure and the esophageal response to volumetric distention"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"D. 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