{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:30:01Z","timestamp":1781148601780,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Common symptoms of gastroparesis include nausea, vomiting, early satiety, postprandial fullness, and upper abdominal pain. Domperidone is used for treatment of gastroparesis. Daily symptom scoring may help document efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the effectiveness of domperidone for gastroparesis symptoms using the gastroparesis cardinal symptom index\u2010daily diary (<jats:styled-content style=\"fixed-case\">GCSI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) and to determine which symptoms improve and when with domperidone treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Symptomatic patients with diabetic or idiopathic gastroparesis were enrolled. Gastric emptying was performed using 4\u00a0hour scintigraphy. <jats:styled-content style=\"fixed-case\">GCSI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> recorded symptoms at baseline and during six weeks of treatment with domperidone 10\u00a0mg <jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GCSI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> records severity of nausea, early satiety, postprandial fullness, upper abdominal pain, overall gastroparesis symptoms on a scale of 0 (no symptom) to 4 (very severe) and records the number of vomiting episodes per day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients with gastroparesis (5 diabetic, 29 idiopathic) participated in this open label study. Treatment duration averaged 36.9\u00a0\u00b1\u00a07.6\u00a0days. Improvement in overall gastroparesis symptoms occurred on day 3 of treatment and maintained during the treatment. Early satiety, postprandial fullness, and overall symptom severity significantly improved from baseline to the final week of treatment (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.05 for all), whereas nausea had borderline improvement (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.055). Side effects included palpitations (5 patients), headache (5), breast tenderness (2), menstrual bleeding (2), dizziness (1), drowsiness (1), chest pain (1), swelling (1), constipation (1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Domperidone improves symptoms of gastroparesis, reducing overall gastroparesis symptom severity and decreasing early satiety, postprandial fullness, and nausea. GCSI\u2010DD is useful to document efficacy of therapy for gastroparesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13246","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T05:16:34Z","timestamp":1510031794000},"source":"Crossref","is-referenced-by-count":26,"title":["Therapeutic response to domperidone in gastroparesis: A\u00a0prospective study using the <scp>GCSI<\/scp>\u2010daily diary"],"prefix":"10.1111","volume":"30","author":[{"given":"J.","family":"Heckert","sequence":"first","affiliation":[{"name":"Gastroenterology Section Temple University School of Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"H. 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Food and Drug Administration Center for Drug Evaluation and Research (CDER). 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