{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:53:08Z","timestamp":1778820788908,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Trond Mohn Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric accommodation to a meal may be important in the pathogenesis of upper gastrointestinal disorders, but has been difficult to investigate in a minimally invasive fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied gastric and lower esophageal physiology during food intake, combining transabdominal ultrasound, multichannel high\u2010resolution impedance\u2010manometry (<jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content>) and a symptom questionnaire. A <jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content> catheter was distally positioned at incisura angularis and 300\u00a0mL saline with 75\u00a0g glucose was ingested. Target variables were recorded for 30\u00a0min after fluid intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Fifteen healthy subjects\u2019 participated (11W\/4M, median age 23.8\u00a0y) and all accepted the meal with few symptoms. At incisura angularis maximum change in pressure from pre\u2010intake values was \u22127.4\u00a0mmHg after 60\u00a0s (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), rising to pre\u2010intake values within 20\u00a0min. The corresponding area increased significantly from pre\u2010intake values of 8.0\u00a0cm<jats:sup>2<\/jats:sup> to 14.1\u00a0cm<jats:sup>2<\/jats:sup> shortly after intake (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0012), peaked at 5\u00a0min and slowly decreased towards 30\u00a0min. The corresponding maximum change in stress from pre\u2010intake pressure values was \u221259.2\u00a0mmHg shortly after (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), reaching pre\u2010intake values within 20\u00a0min. Strain rose from 0 shortly before to 0.36 shortly after (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), peaking at 5\u00a0min. At incisura angularis, fullness was positively correlated with area and to strain, while fullness, area, and stress were negatively correlated with pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The multimodal method enabled assessment of the gastric accommodation reflex, stress and strain in the stomach. It triggered few symptoms in healthy volunteers. We propose it to be a more physiological replacement of the barostat technique.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13249","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T06:06:45Z","timestamp":1510207605000},"source":"Crossref","is-referenced-by-count":10,"title":["Gastric accommodation in healthy subjects studied by ultrasound, manometry, and impedancemetry"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-4747","authenticated-orcid":false,"given":"E. 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