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Immunotherapy has recently been utilized to treat suspected autoimmune gastrointestinal dysmotility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients with symptoms of gastroparesis (Gp) who were refractory to drug\/device were selected from 443\u00a0Gp patients from 2013 to 2015 who were treated at the University of Louisville motility center. All patients underwent a structural and psychiatric evaluation along with detailed psychological and behavioral examination to rule out eating disorders. We performed detailed neuromuscular evaluation and all 14 patients received at least 12\u00a0weeks of intravenous immunoglobulin (400\u00a0mg\/kg infusion weekly). Response was defined subjectively (symptomatic improvement) using standardized <jats:styled-content style=\"fixed-case\">IDIOM<\/jats:styled-content> score system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>All 14 patients had serological evidence and\/or tissue evidence of immunological abnormality. Post\u2010<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> therapy, there was a significant improvement in symptoms scores for nausea, vomiting, early satiety, and abdominal pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Although limited by the absence of placebo group, the data illustrate the role of autoimmunity and neuromuscular evaluation in patients with gastroparesis and support the utility of a diagnostic trial of immunotherapy in an effort to improve therapeutic outcomes for such patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13256","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:29:48Z","timestamp":1512469788000},"source":"Crossref","is-referenced-by-count":23,"title":["Intravenous immunoglobulin in drug and device refractory patients with the symptoms of gastroparesis\u2014an open\u2010label study"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Ashat","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Liaquat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Medicine University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stocker","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Medicine University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"McElmurray","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Medicine University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vedanarayanan","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Medicine University of Mississippi  Oxford MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Soota","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Howell","sequence":"additional","affiliation":[{"name":"GI Motility Clinic Jewish Hospital  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kedar","sequence":"additional","affiliation":[{"name":"Division of Medicine University of Mississippi Medical Center  Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Obert","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Medicine University of Louisville  Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-5161","authenticated-orcid":false,"given":"T. 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