{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:33:15Z","timestamp":1760189595526,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01 DK079902"],"award-info":[{"award-number":["R01 DK079902"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>We hypothesized that symptoms in Jackhammer esophagus (JH<\/jats:styled-content>) are associated with an imbalance between the prepeak and postpeak phases of contraction. Thus, we developed a method to distinguish the contractile integral components of prepeak and postpeak phase contractile activity to determine the contribution of each phase and their association with dysphagia.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients diagnosed with JH<\/jats:styled-content> were enrolled and compared to controls. The first five intact swallows during manometry were analyzed. A single swallow was divided into a prepeak and postpeak phase. The contractile integral of each phase and its corresponding time\u2010controlled integral were computed. All metrics were compared between controls and JH<\/jats:styled-content> patients subcategorized by the impaction dysphagia question (IDQ<\/jats:styled-content>) score with cut\u2010off of 6.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Thirty eight JH<\/jats:styled-content> patients and 71 controls were included. Twelve JH<\/jats:styled-content> patients had IDQ<\/jats:styled-content>\u00a0\u2264\u00a06 and 26 with IDQ<\/jats:styled-content>\u00a0>\u00a06. JH<\/jats:styled-content> patients had higher contractile integral in both phases, and a higher ratio between postpeak to prepeak contractile integral independent of duration. Similarly, JH<\/jats:styled-content> patients with an IDQ<\/jats:styled-content>\u00a0>\u00a06 had higher contractile metrics than those with IDQ<\/jats:styled-content>\u00a0\u2264\u00a06. There was a correlation between the IDQ<\/jats:styled-content> score and the ratio within the postpeak to prepeak contractile integral (r<\/jats:italic>\u00a0=\u00a0.375).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Abnormalities in contractile integral of the postpeak phase are more significant in JH<\/jats:styled-content> with higher dysphagia scores Although the total postpeak contractile integral was higher in symptomatic patients, this was associated with longer duration of postpeak activity suggesting that dysphagia patients with JH<\/jats:styled-content> have a defect in the postpeak phase of peristalsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13262","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:29:04Z","timestamp":1511976544000},"source":"Crossref","is-referenced-by-count":20,"title":["Jackhammer esophagus: Assessing the balance between prepeak and postpeak contractile integral"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-8583","authenticated-orcid":false,"given":"Y.","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"D. A.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-6952","authenticated-orcid":false,"given":"Z.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Alhalel","sequence":"additional","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200607000-00008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-1-66"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.145"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.02.046"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70252-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750305413"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2306.2003.01788.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.313"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90016-6"},{"key":"e_1_2_9_13_1","article-title":"Jackhammer esophagus: observations on a European cohort","author":"Herregods TV","year":"2016","journal-title":"Neurogastroenterol Motil"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:03:18Z","timestamp":1695481398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,29]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/nmo.13262"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13262","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2017,11,29]]},"article-number":"e13262"}}