{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:53:33Z","timestamp":1777388013097,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gebrax"},{"name":"Nestl\u00e9 Nutrition"},{"name":"Universidad Cat\u00f3lica - Christus Health Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lactose intolerance is a frequent condition in certain populations. Different methods for diagnosis exist. There is scarce literature regarding Lactose Quick Test (<jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content>) and concordance with other methods for lactose intolerance diagnosis in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively, we included children who underwent gastroduodenoscopy for evaluation of abdominal pain. We obtained a duodenal sample for <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content> and blood sample for genetic test to evaluate <jats:styled-content style=\"fixed-case\">LCT<\/jats:styled-content> C&gt;T<jats:sub>\u201013910<\/jats:sub> variant. Later, patients underwent breath test with lactose, to evaluate malabsorption. We evaluated the concordance between the three different tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>We included 46 patients, 56.5% women. Mean age was 13.2\u00a0years (range 9\u201018\u00a0years). 66.6% of patients had lactose malabsorption according to breath test; 64.4% were homozygous <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>; and 91.3% had hypolactasia (mild or severe) according to <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content>. None of the patients with normolactasia had altered breath test. Genetic test had a substantial agreement (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.675) with breath test and fair agreement (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.301) with <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content> had fair agreement (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.348) with breath test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Genetic test had better concordance with breath test than <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content> to diagnose lactose malabsorption, however, none of the patients with normal <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content> had lactose malabsorption. In patients who undergo gastroduodenoscopy to study abdominal pain, it seems reasonable to perform <jats:styled-content style=\"fixed-case\">LQT<\/jats:styled-content>, and, in those with hypolactasia, to perform breath test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13271","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T15:55:02Z","timestamp":1513871702000},"source":"Crossref","is-referenced-by-count":9,"title":["Concordance between Lactose Quick Test, hydrogen\u2010methane breath test and genotyping for the diagnosis of lactose malabsorption in children"],"prefix":"10.1111","volume":"30","author":[{"given":"C.","family":"Rojo","sequence":"first","affiliation":[{"name":"Faculty of Medicine Division of Pediatrics Department of Pediatric Gastroenterology and Nutrition Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Hospital Regional Leonardo Guzm\u00e1n  Antofagasta Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-8537","authenticated-orcid":false,"given":"F.","family":"Jaime","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Division of Pediatrics Department of Pediatric Gastroenterology and Nutrition Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Az\u00f3car","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Departament of Gastroenterology Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Division of Pediatrics Department of Pediatric Gastroenterology and Nutrition Laboratory of Gastrointestinal Infections and Immunology Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Villagr\u00e1n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Division of Pediatrics Department of Pediatric Gastroenterology and Nutrition Laboratory of Gastrointestinal Infections and Immunology Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Miquel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Departament of Gastroenterology Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Arancibia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Division of Pediatrics Department of Pediatric Gastroenterology and Nutrition Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1157\/13124885"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086251"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03557.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31812e68f6"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"1","article-title":"Methodology and indications of H2\u2010breath testing in gastrointestinal diseases: the Rome Consensus Conference","volume":"29","author":"Gasbarrini A","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"S9","article-title":"Lactose intolerance","volume":"24","author":"Vandenplas Y","year":"2015","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001208"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365518409161400"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318231eb30"},{"key":"e_1_2_9_12_1","first-page":"1101","article-title":"[Comparative performance of symptoms questionnaire, hydrogen test and genetic test for lactose intolerance]","volume":"140","author":"Roll\u00e1n A","year":"2012","journal-title":"Rev Med Chile"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31824e9132"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0443-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2980-7"},{"key":"e_1_2_9_17_1","first-page":"135","article-title":"Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre","volume":"17","author":"Krawczyk M","year":"2008","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363229"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.22594"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000125"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.09.020"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.11.001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925354"},{"key":"e_1_2_9_24_1","first-page":"256","article-title":"[Prevalence of hypolactasia in Chilean schoolchildren from Santiago city]","volume":"40","author":"Cruchet S","year":"2013","journal-title":"Rev Chil Nutr"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/10\/1\/016015"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:03:34Z","timestamp":1695481414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/nmo.13271"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13271","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,21]]},"article-number":"e13271"}}