{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:47Z","timestamp":1753878707451,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["502\u201003\/1\u2010156\u201004\/502\u201014\u2010343","503\/1\u2010156\u201004\/503\u201011\u2010001"],"award-info":[{"award-number":["502\u201003\/1\u2010156\u201004\/502\u201014\u2010343","503\/1\u2010156\u201004\/503\u201011\u2010001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The role of fatty acid binding protein 4 (FABP<\/jats:styled-content>4) in lower gastrointestinal (GI<\/jats:styled-content>) motility is unknown. We aimed to verify the effect of inhibition of FABP<\/jats:styled-content>4 on GI<\/jats:styled-content> transit in vivo, and to determine the expression of FABP<\/jats:styled-content>4 in mouse and human tissues.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fatty acid binding protein 4 inhibitor, BMS<\/jats:styled-content>309403, was administered acutely or chronically for 6 and 13 consecutive days and its effect on GI<\/jats:styled-content> transit was assessed in physiological conditions and in loperamide\u2010induced constipation. Intracellular recordings were made to examine the effects of BMS<\/jats:styled-content>309403 on colonic excitatory and inhibitory junction potentials. Abdominal pain was evaluated using behavioral pain response. Localization and expression of selected adipokines were determined in the mouse colon and serum using immunohistochemistry and Enzyme\u2010Linked ImmunoSorbent Assay respectively. mRNA<\/jats:styled-content> expression of FABP<\/jats:styled-content>4 and selected adipokines in colonic and serum samples from irritable bowel syndrome (IBS<\/jats:styled-content>) patients and control group were assessed.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Acute injection of BMS<\/jats:styled-content>309403 significantly increased GI<\/jats:styled-content> motility and reversed inhibitory effect of loperamide. BMS<\/jats:styled-content>309403 did not change colonic membrane potentials. Chronic treatment with BMS<\/jats:styled-content>309403 increased the number of pain\u2010induced behaviors. In the mouse serum, level of resistin was significantly decreased after acute administration; no changes in adiponectin level were detected. In the human serum, level of adiponectin and resistin, but not of FABP<\/jats:styled-content>4, were significantly elevated in patients with constipation\u2010IBS<\/jats:styled-content> (IBS<\/jats:styled-content>\u2010C). FABP<\/jats:styled-content>4 mRNA<\/jats:styled-content> expression was significantly downregulated in the human colon in IBS<\/jats:styled-content>\u2010C.<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>Fatty acid binding protein 4 may be involved in IBS<\/jats:styled-content> pathogenesis and become a novel target in the treatment of constipation\u2010related diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13272","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T08:42:44Z","timestamp":1513759364000},"source":"Crossref","is-referenced-by-count":8,"title":["FABP<\/scp>4 blocker attenuates colonic hypomotility and modulates white adipose tissue\u2010derived hormone levels in mouse models mimicking constipation\u2010predominant IBS<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"given":"P.","family":"Mosi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Jacenik","sequence":"additional","affiliation":[{"name":"Department of Cytobiochemistry Faculty of Biology and Environmental Protection University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sa\u0142aga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wasilewski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cygankiewicz","sequence":"additional","affiliation":[{"name":"Department of Cytobiochemistry Faculty of Biology and Environmental Protection University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sibaev","sequence":"additional","affiliation":[{"name":"Walter Brendel Center of Experimental Medicine Ludwig Maximilians University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mokrowiecka","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Disease Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ma\u0142ecka\u2010Panas","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Disease Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Pintelon","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Histology Department of Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Storr","sequence":"additional","affiliation":[{"name":"Walter Brendel Center of Experimental Medicine Ludwig Maximilians University of Munich Munich Germany"},{"name":"Center of Endoscopy Stanberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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