{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:51:59Z","timestamp":1761562319402,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dysphagia and non\u2010cardiac chest pain are common symptoms associated with a novel hypercontractile disorder, namely Jackhammer esophagus (<jats:styled-content style=\"fixed-case\">JE<\/jats:styled-content>). The aim of this study was to explore these symptoms in patients with <jats:styled-content style=\"fixed-case\">JE<\/jats:styled-content> and to elucidate associations with disease defining metrics, crucial for subsequent therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive patients, who were referred between January 2014 and December 2016 and fulfilled the criteria for <jats:styled-content style=\"fixed-case\">JE<\/jats:styled-content> were included in this study. Exclusion criteria were opioid intake, previous gastrointestinal surgery, mechanical esophageal obstruction and diseases explaining their symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Of 2205 examined subjects, thirty patients (females: n\u00a0=\u00a017, 56.7%) with a median age of 58 (51.6\u201064.9) years were finally enrolled. Dysphagia was noted in 53.3% (n\u00a0=\u00a016), whereas non\u2010cardiac chest pain was specified within 40% (n\u00a0=\u00a012) with symptom duration of up to 10\u00a0years. Perception of dysphagia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and presence of both symptoms (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) increased to the end of the study period. Dysphagia was significantly associated with distal contractile integral (<jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content>) scores of all (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.023), hypercontractile (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.011) and maximum <jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content> swallows (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). Symptoms duration influenced hypercontractile <jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content> scores (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.438) and significantly correlated with the intensity of perceived dysphagia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.585). Presence of non\u2010cardiac chest pain was not associated with any of these metrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Interferences<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content> mediates dysphagia in patients with <jats:styled-content style=\"fixed-case\">JE<\/jats:styled-content>. Duration of symptoms affected hypercontractile <jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content> scores and aggravated perception of dysphagia indicating a progressive character of disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13276","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T15:31:13Z","timestamp":1513870273000},"source":"Crossref","is-referenced-by-count":20,"title":["Dysphagia severity is related to the amplitude of distal contractile integral in patients with Jackhammer esophagus"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-1625","authenticated-orcid":false,"given":"I.","family":"Kristo","sequence":"first","affiliation":[{"name":"Department of Surgery Upper GI Research &amp; Service Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Schwameis","sequence":"additional","affiliation":[{"name":"Department of Surgery Upper GI Research &amp; Service Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Paireder","sequence":"additional","affiliation":[{"name":"Department of Surgery Upper GI Research &amp; Service Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Jomrich","sequence":"additional","affiliation":[{"name":"Department of Surgery Upper GI Research &amp; Service Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kainz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F.","family":"Schoppmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Upper GI Research &amp; Service Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03178.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01834.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.313"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.030"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12975"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-105204"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12328"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(84)72448-5"},{"key":"e_1_2_9_12_1","first-page":"2341","article-title":"Modern GERD treatment: feasibility of minimally invasive esophageal sphincter augmentation","volume":"34","author":"Schwameis K","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12285"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70252-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200309000-00004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90008-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2012.11.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01578.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01086.x"},{"issue":"4","key":"e_1_2_9_20_1","first-page":"iv69","article-title":"Spinal and supraspinal modulation of visceral sensation","volume":"47","author":"Mayer EA","year":"2000","journal-title":"Gut"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.10.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12182"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.021"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03791.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2015.5865"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15162"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12953"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12642"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032015000100007"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:03:37Z","timestamp":1695481417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/nmo.13276"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13276","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2017,12,21]]},"article-number":"e13276"}}