{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:23:29Z","timestamp":1773501809965,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cardiorespiratory (CR<\/jats:styled-content>) events (apnea, bradycardia, oxygen desaturation) and gastroesophageal reflux (GER<\/jats:styled-content>) symptoms often coexist in infants admitted to Neonatal Intensive Care Unit, leading to over\u2010prescription of drugs and delayed discharge. We aimed to evaluate the relationships between CR<\/jats:styled-content> and GER<\/jats:styled-content> events.<\/jats:p><\/jats:sec>Methods<\/jats:title>The temporal associations between CR<\/jats:styled-content> and GER<\/jats:styled-content> events were analyzed in symptomatic infants who underwent synchronized CR<\/jats:styled-content> and pH<\/jats:styled-content>\u2010impedance monitoring. The symptom association probability (SAP<\/jats:styled-content>) index was used to identify infants with a significant number of temporal associations. Gastroesophageal reflux characteristics and the chronological sequence of CR<\/jats:styled-content> and GER<\/jats:styled-content> events occurring within 30\u00a0seconds of each other were evaluated according to SAP<\/jats:styled-content> index.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Of the 66 infants enrolled, aged 29 (18\u201045) days, 58 had CR<\/jats:styled-content> events during monitoring. From these 58 patients, a total of 1331 CR<\/jats:styled-content> events and 5239 GER<\/jats:styled-content> (24% acidic) were detected. The SAP<\/jats:styled-content> index was positive in seven (12%) infants. These infants had greater GER<\/jats:styled-content> frequency, duration, and proximal extent (P<\/jats:italic>\u00a0<\u00a0.05). The number of temporal associations was 10 times greater in the positive SAP<\/jats:styled-content> group. Gastroesophageal reflux events preceded CR<\/jats:styled-content> events in 83% of these associations. These GER<\/jats:styled-content> events had a higher proximal extent (P<\/jats:italic>\u00a0=\u00a0.004), but showed no differences in pH<\/jats:styled-content> values.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>The simultaneous evaluation of CR<\/jats:styled-content> and GER<\/jats:styled-content> events could be useful to identify infants with severe GER<\/jats:styled-content> and significant temporal associations between these events. Treatment of GER<\/jats:styled-content> could be indicated in these infants, but as the GER<\/jats:styled-content> events involved are mainly non\u2010acidic, empirical treatment with antacids is, often, inappropriate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13278","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:14:09Z","timestamp":1513872849000},"source":"Crossref","is-referenced-by-count":21,"title":["Cardiorespiratory events in infants with gastroesophageal reflux symptoms: Is there any association?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2139-6855","authenticated-orcid":false,"given":"F.","family":"Cresi","sequence":"first","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit Department of Public Health and Pediatrics University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit Department of Biomedical Science and Human Oncology \u201cAldo Moro\u201d University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Maggiora","sequence":"additional","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit Department of Public Health and Pediatrics University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit Department of Public Health and Pediatrics University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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