{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:34:59Z","timestamp":1792510499901,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Esophago\u2010gastric junction (EGJ<\/jats:styled-content>) outflow obstruction is of unclear significance. Rapid drink challenge (RDC<\/jats:styled-content>) test is easy to perform during esophageal high resolution manometry. We aimed to assess the yield of RDC<\/jats:styled-content> test in patients with EGJ<\/jats:styled-content> outflow obstruction.<\/jats:p><\/jats:sec>Methods<\/jats:title>Manometry studies of patients with EGJ<\/jats:styled-content> outflow obstruction according to the Chicago Classification v3.0 were retrospectively reviewed. Pan\u2010esophageal pressurization (PEP<\/jats:styled-content>), esophageal shortening, and pressure gradient across the EGJ<\/jats:styled-content> were analyzed during RDC<\/jats:styled-content> test (200\u2010mL free drinking in sitting position) and compared according to the causes of EGJ<\/jats:styled-content> outflow obstruction determined by charts review.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Seventy\u2010five patients (29 males, mean age 62\u00a0years) were included. Causes of EGJ<\/jats:styled-content> outflow obstruction were previous esophago\u2010gastric surgery (40%), incomplete form of achalasia (7%), mediastinal neoplasia (7%), other associated conditions (21%), and undetermined (25%). Rapid drink challenge test was successfully performed in 70 patients and associated with PEP<\/jats:styled-content> and shortening in 41% and 13%, respectively. The causes of EGJ<\/jats:styled-content> outflow obstruction were similarly distributed in patients with and without PEP<\/jats:styled-content> during RDC<\/jats:styled-content> test. Esophageal shortening tended to be more likely in patients with definitive findings of obstruction (achalasia, previous surgery, neoplasia) than in the others. Dysphagia was more severe in patients with PEP<\/jats:styled-content> and\/or shortening during RDC<\/jats:styled-content> test compared to those without.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Pan\u2010esophageal pressurization and esophageal shortening were associated with symptoms severity but did not predict the cause of this disorder. Further prospective studies are necessary to determine if RDC<\/jats:styled-content> test could help to select patients who might benefit from treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13293","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T19:15:40Z","timestamp":1516648540000},"source":"Crossref","is-referenced-by-count":55,"title":["Rapid drink challenge test during esophageal high resolution manometry in patients with esophago\u2010gastric junction outflow obstruction"],"prefix":"10.1111","volume":"30","author":[{"given":"D.","family":"Biasutto","sequence":"first","affiliation":[{"name":"Hopital E Herriot Digestive Physiology Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"},{"name":"Digestive Physiology Lyon I University Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-1591","authenticated-orcid":false,"given":"F.","family":"Mion","sequence":"additional","affiliation":[{"name":"Hopital E Herriot Digestive Physiology Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"},{"name":"Digestive Physiology Lyon I University Universit\u00e9 de Lyon Lyon France"},{"name":"LabTAU Inserm U1032 Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garros","sequence":"additional","affiliation":[{"name":"Hopital E Herriot Digestive Physiology Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7638","authenticated-orcid":false,"given":"S.","family":"Roman","sequence":"additional","affiliation":[{"name":"Hopital E Herriot Digestive Physiology Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"},{"name":"Digestive Physiology Lyon I University Universit\u00e9 de Lyon Lyon France"},{"name":"LabTAU Inserm U1032 Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12071"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01834.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0975-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.154"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12708"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12625"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12902"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12749"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04142.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91428-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12920"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13061"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12554"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01672.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13105"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:18:44Z","timestamp":1695482324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/nmo.13293"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13293","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"article-number":"e13293"}}