{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:51:21Z","timestamp":1787507481404,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006362","name":"Neuroscience Nursing Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ghrelin, an orexigenic peptide, is secreted from endocrine cells in the gastric mucosa. Circulating levels rise in the preprandial phase, suggesting an anticipatory or cephalic phase of release, and decline in the postprandial phase, suggesting either the loss of a stimulatory factor or inhibition by factors released when nutrients enter the intestine. We hypothesized that vagal signals are not required for the (i) preprandial increase or (ii) postprandial suppression of ghrelin levels. Further, we wanted to investigate the hypothesis that (iii) glucagon\u2010like peptide\u20101 might be implicated in the postprandial decline in ghrelin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We measured ghrelin levels in plasma from sham\u2010feeding and meal studies carried out in vagotomized individuals and controls, and from a\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101 infusion study carried out in fasting healthy young individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      We find that (i) ghrelin secretion is unchanged during indirect vagal stimulation as elicited by modified sham\u2010feeding in vagotomized individuals and matched controls, (ii) ghrelin secretion is similarly suppressed after meal ingestion in vagotomized individuals and controls, and (iii) infusion of\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101 does not lower ghrelin levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; inferences<\/jats:title>\n                    <jats:p>\n                      We conclude that for postprandial suppression of circulating ghrelin levels, a circulating factor (but not\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101) or short (duodeno\u2010gastric) reflexes seem to be implicated.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13295","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T03:22:37Z","timestamp":1517541757000},"source":"Crossref","is-referenced-by-count":18,"title":["Ghrelin secretion in humans \u2013 a role for the vagus nerve?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-3417","authenticated-orcid":false,"given":"S.","family":"Veedfald","sequence":"first","affiliation":[{"name":"Endocrinology Research Section Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Section for Translational Metabolic Physiology Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Diabetes Research Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Surgical Gastroenterology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Plamboeck","sequence":"additional","affiliation":[{"name":"Endocrinology Research Section Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Section for Translational Metabolic Physiology Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Endocrinology Research Section Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Section for Translational Metabolic Physiology Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Steno Diabetes Center Copenhagen University of Copenhagen  Gentofte Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Section for Translational Metabolic Physiology Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Diabetes Research Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Deacon","sequence":"additional","affiliation":[{"name":"Endocrinology Research Section Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Section for Translational Metabolic Physiology Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. B.","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Endocrinology Research Section Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Section for Translational Metabolic Physiology Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7885"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1714"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031267"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1059"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(03)00195-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00634.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9022-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032222"},{"key":"e_1_2_10_10_1","article-title":"Cephalic phase secretion of insulin and other entero\u2010pancreatic hormones in humans","volume":"310","author":"Veedfald S","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0656"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031517"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.03.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.10.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00569.2013"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0264"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00035.2013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00123.2015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.20.11.1020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.12.1003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0243"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0381"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030204"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1705-7"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T11:18:21Z","timestamp":1695467901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,2]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/nmo.13295"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13295","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,2]]},"article-number":"e13295"}}