{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:42:43Z","timestamp":1776951763458,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proximal reflux and incomplete transit of boluses swallowed are risk factors for obstructive chronic lung allograft dysfunction (o\u2010<jats:styled-content style=\"fixed-case\">CLAD<\/jats:styled-content>) post\u2010lung transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x). Likewise, so is esophagogastric junction outflow obstruction (<jats:styled-content style=\"fixed-case\">EGJOO<\/jats:styled-content>), but not hypo\u2010contractility, when diagnosed using Chicago Classification (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) v3.0. Given, peristaltic breaks as defined using <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v2.0 can prolong esophageal clearance, both swallowed and refluxed, but which are deemed within normality using <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v3.0, our aim was to determine whether hypo\u2010contractility as diagnosed using <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v2.0, influences the association with reflux, along with its clearance, and that of boluses swallowed, and thus its association to allograft failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Esophageal motility abnormalities were classified using <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> v3.0 and v2.0 in 50 patients post\u2010LTx\u00a0(26 female, 55\u00a0years (20\u201073\u00a0years)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reclassification from <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v3.0 to v2.0 resulted in 7 patients with normal motility being reclassified to hypo\u2010contractility (n\u00a0=\u00a06) or hyper\u2010contractility (n\u00a0=\u00a01); 2 patients with hypo\u2010contractility to normal motility; and 3 patients with <jats:styled-content style=\"fixed-case\">EGJOO<\/jats:styled-content> without hyper\u2010contractility to <jats:styled-content style=\"fixed-case\">EGJOO<\/jats:styled-content> with hyper\u2010contractility. The main consequence of reclassification was that the sub\u2010group exhibiting hypo\u2010contractility became more likely to have abnormal numbers of reflux events (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.025) and incomplete bolus transit (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) than those with normal motility using <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v2.0; associations not seen using <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v3.0. Irrespective of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> used only patients with <jats:styled-content style=\"fixed-case\">EGJOO<\/jats:styled-content> appeared more likely to develop o\u2010<jats:styled-content style=\"fixed-case\">CLAD<\/jats:styled-content> than those with normal motility (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Irrespective of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> used, o\u2010<jats:styled-content style=\"fixed-case\">CLAD<\/jats:styled-content> appears linked to <jats:styled-content style=\"fixed-case\">EGJOO<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>v2.0 however, accentuates the increased reflux and incomplete bolus transit associated with hypo\u2010contractility post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x, suggesting that these motor abnormalities, though considered minor, may be of importance after lung transplant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13296","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T10:56:39Z","timestamp":1518000999000},"source":"Crossref","is-referenced-by-count":11,"title":["Esophageal dysmotility according to Chicago classification v3.0 vs v2.0: Implications for association with reflux, bolus clearance, and allograft failure post\u2010lung transplantation"],"prefix":"10.1111","volume":"30","author":[{"given":"A.","family":"Tangaroonsanti","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville FL USA"},{"name":"Department of Gastroenterology Thammasat University Hospital  Pathumthani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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A.","family":"Houghton","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville FL USA"},{"name":"Leeds Institute of Biomedical and Clinical Sciences Leeds Gastroenterology Institute Leeds Teaching Hospitals Trust University of Leeds  Leeds UK"},{"name":"Centre for Gastrointestinal Sciences University Hospital of South Manchester Manchester Academic Health Sciences Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.06.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.07.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0b013e31824017d4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.07.019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.05.038"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.5.1689"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2003.00060.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.30"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.373"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12513"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.712"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.10.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107514"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01834.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283530f62"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.384"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(03)70033-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04172.x"},{"key":"e_1_2_9_21_1","first-page":"A","article-title":"Normal values for ambulatory 24\u2010h combined impedance\u2010ph monitoring on acid suppressive therapy","volume":"130","author":"Tutuian R","year":"2006","journal-title":"Gastroenterology"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.07.038"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.06.089"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:18:23Z","timestamp":1695482303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,7]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/nmo.13296"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13296","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,7]]},"article-number":"e13296"}}