{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:50:47Z","timestamp":1773183047834,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["no. 2012CB518500"],"award-info":[{"award-number":["no. 2012CB518500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To test the efficacy of electroacupuncture for patients with refractory functional dyspepsia (FD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 24\u2010week, 2\u2010arm, single\u2010blind, randomized controlled trial was conducted at three hospitals in China. Patients with refractory FD were randomly assigned to receive 20 sessions of authentic or sham electroacupuncture in a treatment duration of 4\u00a0weeks. The primary outcome was complete absence of dyspeptic symptoms at 16\u00a0weeks after initiation of acupuncture (week 16). The secondary outcomes included adequate relief of dyspeptic symptoms, Leeds Dyspepsia Questionnaire (<jats:styled-content style=\"fixed-case\">LDQ<\/jats:styled-content>), Nepean Dyspepsia Index (<jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>), and adverse events. Intention\u2010to\u2010treat analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Two hundred patients were included, of which 196 (98%) completed follow\u2010up data at week 24. At week 16, 17 (17%) patients in the authentic electroacupuncture group vs 6 (6%) patients in the sham group achieved the primary outcome (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.014). Sixty\u2010two (62%) patients had adequate relief in the authentic electroacupuncture group, as compared to 22 (22%) in the sham group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The scores of <jats:styled-content style=\"fixed-case\">LDQ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content> were significantly improved in both groups at week 16, and patients in the authentic electroacupuncture group have more improvements (<jats:styled-content style=\"fixed-case\">LDQ<\/jats:styled-content>, mean difference, \u22122.2, 95% confidence interval, \u22122.3 to \u22122.1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; <jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>, \u22127.3, \u221210.5 to \u22124.2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Results were similar for all the outcomes assessed at week 24. No serious adverse events were reported in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acupuncture efficaciously improves dyspeptic symptoms in patients with refractory FD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13316","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T06:36:41Z","timestamp":1519799801000},"source":"Crossref","is-referenced-by-count":38,"title":["Electroacupuncture for patients with refractory functional dyspepsia: A randomized controlled trial"],"prefix":"10.1111","volume":"30","author":[{"given":"H.","family":"Zheng","sequence":"first","affiliation":[{"name":"Acupuncture &amp; Tuina College\/3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[{"name":"Acupuncture &amp; Tuina College\/3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Evidence\u2010based Medicine Centre West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Acupuncture &amp; 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