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The autonomic nervous system (\n ANS<\/jats:styled-content>\n ) is part of the bidirectional brain\u2010gut communication, but previous studies in\n IBS<\/jats:styled-content>\n show diverging results. We aimed to identify subgroups of\n IBS<\/jats:styled-content>\n patients with distinct\n ANS<\/jats:styled-content>\n characteristics differentiating them from healthy controls (\n HC<\/jats:styled-content>\n ), and to study associations between\n ANS<\/jats:styled-content>\n status and symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Heart rate variability (\n HRV<\/jats:styled-content>\n ) was measured in\n IBS<\/jats:styled-content>\n patients and\n HC<\/jats:styled-content>\n (Holter monitoring: supine and standing positions with controlled respiration and ambulatory 24\u2010hour period). Frequency (5\u00a0minutes, supine, standing) and time domains (24\u00a0hours, day, night) were analyzed. Validated questionnaires were used to measure gastrointestinal and psychological symptoms in patients. Patients and\n HC<\/jats:styled-content>\n were compared on a univariate and multivariate level (principal component analysis [\n PCA<\/jats:styled-content>\n ] and orthogonal partial least squares discriminatory analysis (\n OPLS<\/jats:styled-content>\n \u2010\n DA<\/jats:styled-content>\n )).\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n We analyzed 158\n IBS<\/jats:styled-content>\n patients (Rome\n III<\/jats:styled-content>\n ) and 39\n HC<\/jats:styled-content>\n . Patients differed significantly from\n HC<\/jats:styled-content>\n in\n HRV<\/jats:styled-content>\n parameters during daytime and in standing position. In the\n PCA<\/jats:styled-content>\n , a majority of patients overlapped with\n HC<\/jats:styled-content>\n , but the weighted means differed (\n P<\/jats:italic>\n \u00a0<\u00a0.01). A subset of patients (n\u00a0=\u00a030; 19%) with an aberrant global\n HRV<\/jats:styled-content>\n profile was identified through\n PCA<\/jats:styled-content>\n and\n OPLS<\/jats:styled-content>\n \u2010\n DA<\/jats:styled-content>\n ; these patients reported more severe symptoms of frequent (\n P<\/jats:italic>\n \u00a0<\u00a0.05) and loose stools (\n P<\/jats:italic>\n \u00a0=\u00a0.03), as well as urgency (\n P<\/jats:italic>\n \u00a0=\u00a0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Inferences<\/jats:title>\n \n Altered\n ANS<\/jats:styled-content>\n function was demonstrated in patients with\n IBS<\/jats:styled-content>\n , and this might be of particular relevance for symptoms in a subset of the patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.13320","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T03:41:06Z","timestamp":1521949266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Heart rate variability characteristics of patients with irritable bowel syndrome and associations with symptoms"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-7051","authenticated-orcid":false,"given":"A.","family":"Polster","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Sahlgrenska University Hospital G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Friberg","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Sahlgrenska Academy at G\u00f6teborg University G\u00f6teborg 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