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Assessment of treatment efficacy in<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>is a methodological challenge as response to treatment must be assessed primarily by measuring subjective symptoms. Therefore, the use of patient\u2010reported outcome measures (<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>s) is recommended by regulatory authorities to assess gastrointestinal symptoms in clinical trials for<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. In the last decades, a multitude of outcome measures has been developed. However, currently no<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>has been approved by the regulatory authorities, and no consensus has been reached with regard to the most relevant outcome measure in<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This systematic review discusses the available disease\u2010specific outcome measures for assessment of<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>symptoms with psychometric validation properties, strengths, and limitations. Moreover, recommendations for use of current available outcome measures are provided, and potential areas of future research are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13327","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T05:32:40Z","timestamp":1520573560000},"source":"Crossref","is-referenced-by-count":9,"title":["Systematic review: Disease\u2010specific instruments to assess gastrointestinal symptoms in functional dyspepsia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-8312","authenticated-orcid":false,"given":"F. G. 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