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Neuroimaging studies have identified that insula is involved in the pathogenesis of\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      . However, less is known about structural and functional connectivity of insula in\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, 67\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients and 46 healthy controls (\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      s) underwent structural MRI, resting\u2010state functional\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      , diffusion tensor imaging (\n                      <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>\n                      ) scans, and clinical assessment. We used the 3 neuroimaging modalities to investigate structural and functional connectivity of insula between\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients and\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      s, and we examined relationships between the neuroimaging findings and clinical symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Compared with\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      s, (i)\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients had decreased gray matter density in right insula according to voxel\u2010based morphometry method, which region was targeted as region of interest for further analysis of structural and functional connectivity; (ii)\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients had lower connection probability in right anterior insula with right thalamus, right internal capsule (\n                      <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\n                      ), and right external capsule (\n                      <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\n                      ); (iii)\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients had decreased functional connectivity of the right anterior insula with right thalamus and right pregenual anterior cingulate cortex (\n                      <jats:styled-content style=\"fixed-case\">pACC<\/jats:styled-content>\n                      ); and (iv)\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients had negative correlation between disease duration and the functional connectivity of right anterior insula with thalamus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>\n                      The present findings reveal that alterations of structural and\/or functional connectivity of right anterior insula with regions, including thalamus,\n                      <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">pACC<\/jats:styled-content>\n                      , may be mainly implicated in abnormalities of visceral sensory processing and related affective responses in\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients. Finally, this study could enhance understanding of the pathophysiology of\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13345","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T01:49:15Z","timestamp":1524534555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Altered structural and functional connectivity of the insula in functional dyspepsia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-8001","authenticated-orcid":false,"given":"P.","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Life Science Research Center Xidian University  Xi'an China"},{"name":"School of Life Science and Technology Engineering Research Center of Molecular and 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Tuina School Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Life Science Research Center Xidian University  Xi'an China"},{"name":"School of Life Science and Technology Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xidian University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fei","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Life Science Research Center Xidian University  Xi'an China"},{"name":"School of Life Science and Technology Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xidian University  Xi'an 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