{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:04:49Z","timestamp":1783004689182,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_166670"],"award-info":[{"award-number":["320030_166670"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Joint hypermobility syndrome (JHS<\/jats:styled-content>) is characterized by excessive connective tissue laxity manifest as joint hypermobility (JH<\/jats:styled-content>) together with musculoskeletal symptoms. Previous studies have shown an association between JH<\/jats:styled-content>\/JHS<\/jats:styled-content> and gastrointestinal symptoms, including irritable bowel syndrome (IBS<\/jats:styled-content>), although its association with specific IBS<\/jats:styled-content> subtypes is incompletely understood. We aimed to determine the prevalence of JH<\/jats:styled-content> according to the subtypes of IBS<\/jats:styled-content>, in particular IBS<\/jats:styled-content>\u2010C and IBS<\/jats:styled-content>\u2010D.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data of 228 consecutive IBS<\/jats:styled-content> patients were analyzed. IBS<\/jats:styled-content> was subtyped into constipation and diarrhea predominant IBS<\/jats:styled-content> (IBS<\/jats:styled-content>\u2010C and IBS<\/jats:styled-content>\u2010D), IBS<\/jats:styled-content> with mixed bowel habits (IBS<\/jats:styled-content>\u2010M) and unsubtyped IBS<\/jats:styled-content> (IBS<\/jats:styled-content>\u2010U). JH<\/jats:styled-content> was defined as a Beighton Score \u22654\/9 points and JHS<\/jats:styled-content> diagnosed according to revised Brighton Criteria. Data of IBS<\/jats:styled-content> patients were analyzed for psychological comorbidities assessed by Hospital Anxiety and Depression Scale (HADS<\/jats:styled-content>) and Visceral Sensitivity Index (VSI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Key Results<\/jats:title>Of 228 IBS<\/jats:styled-content> patients, 64 (28.1%) suffered from IBS<\/jats:styled-content>\u2010C, 89 (39.0%) from IBS<\/jats:styled-content>\u2010D, 48 (21.1%) from IBS<\/jats:styled-content>\u2010M, and 27 (11.8%) from IBS<\/jats:styled-content>\u2010U. JH<\/jats:styled-content> was diagnosed in 95 patients (41.7%). The prevalence of JH<\/jats:styled-content> was significantly higher in IBS<\/jats:styled-content>\u2010C than IBS<\/jats:styled-content>\u2010D (57.8% vs 34.8%, P<\/jats:italic>\u00a0=\u00a0.031). There was no significant difference in VSI<\/jats:styled-content> and HADS<\/jats:styled-content> according to JH<\/jats:styled-content> or IBS<\/jats:styled-content> subtype.<\/jats:p><\/jats:sec>Conclusions and Interferences<\/jats:title>The prevalence of JH<\/jats:styled-content> was significantly higher in IBS<\/jats:styled-content>\u2010C compared to IBS<\/jats:styled-content>\u2010D. Abnormalities in the connective tissue biomechanics in those with JH<\/jats:styled-content> may contribute to a degree of colonic inertia which could result in constipation in JH<\/jats:styled-content>\u2010positive IBS<\/jats:styled-content> patients. Further work is needed to determine the colonic biomechanics in patients with JH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13353","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T06:05:55Z","timestamp":1524549955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Higher prevalence of joint hypermobility in constipation predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"A.","family":"Zweig","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5112-8504","authenticated-orcid":false,"given":"V.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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