{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:15:42Z","timestamp":1790417742563,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swedish Patients\u2019 Organizations FAMY Norrbotten and V\u00e4sterbotten"},{"name":"AMYL Foundation"},{"name":"Swedish Gastroenterology Fund (Mag-tarmfonden)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastrointestinal complications are common in hereditary transthyretin amyloid (<jats:styled-content style=\"fixed-case\">ATTR<\/jats:styled-content>m) amyloidosis. The underlying mechanisms have not been fully elucidated, and the patients\u2019 small bowel function remains largely unexplored. The aim of the present study was to compare the small bowel motility in <jats:styled-content style=\"fixed-case\">ATTR<\/jats:styled-content>m amyloidosis patients with that in non\u2010amyloidosis patient controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ATTR<\/jats:styled-content>m amyloidosis patients undergoing evaluation for liver transplantation were consecutively investigated with 24\u2010hour duodenojejunal manometry (n\u00a0=\u00a019). The somatostatin analogue octreotide was used to induce fasting motility. Patients with age at onset of \u226550\u00a0years were defined as late\u2010onset cases. For each patient, three age\u2010 and sex\u2010matched patient controls (n\u00a0=\u00a057) were selected from the total pool of investigated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Manometry was judged as abnormal in 58% of the patients and in 26% of the patient controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Patients displayed significantly more daytime phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> migrating motor complexes than patient controls (median 4 vs 2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), and had a higher frequency of low\u2010amplitude complexes (16% vs 4%; however, this difference did not reach statistical significance, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.10). Furthermore, late\u2010onset patients showed a delay in octreotide response (5.4 vs 3.8\u00a0minutes, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), but this was not observed for early\u2010onset patients or within the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">ATTR<\/jats:styled-content>m amyloidosis displayed abnormalities in their small bowel motility more frequently than non\u2010amyloidosis patient controls, and the manometric pattern was probably best consistent with a combined neuromyopathic disorder. The delayed octreotide response in late\u2010onset patients warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13354","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T23:24:46Z","timestamp":1523748286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Abnormal small bowel motility in patients with hereditary transthyretin amyloidosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-1277","authenticated-orcid":false,"given":"J.","family":"Wixner","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"T\u00f6rnblom","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; Clinical Nutrition Sahlgrenska Academy Gothenburg University  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