{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:27:45Z","timestamp":1790965665126,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Conventional anorectal manometric parameters based on linear waves cannot properly predict balloon expulsion (BE<\/jats:styled-content>) time. We aimed to determine the correlation between integrated pressurized volume (IPV<\/jats:styled-content>) parameters during simulated evacuation (SE<\/jats:styled-content>) and BE<\/jats:styled-content> time in healthy individuals and constipated patients and to assess the correlation between each parameter and symptoms.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 230 male participants (including 26 healthy volunteers and 204 chronically constipated patients) underwent high\u2010resolution anorectal manometry (HRAM<\/jats:styled-content>) and BE<\/jats:styled-content> tests. The IPV<\/jats:styled-content> was calculated by multiplying the amplitude, distance, and time from the HRAM<\/jats:styled-content> profile. Receiver operating characteristic curve (ROC<\/jats:styled-content>) analysis and partial least square regression (PLSR<\/jats:styled-content>) were performed.<\/jats:p><\/jats:sec>Key Results<\/jats:title>ROC<\/jats:styled-content> analysis indicated that the IPV<\/jats:styled-content> ratio between the upper 1\u00a0cm and lower 4\u00a0cm of the anal canal was more effective for predicting BE<\/jats:styled-content> time (area under the curve [AUC<\/jats:styled-content>]: 0.74, 95% confidence interval [CI<\/jats:styled-content>]: 0.67\u20100.80, P<\/jats:italic>\u00a0<\u00a0.01) than the conventional anorectal parameters, including defecation index and rectoanal gradient (AUC<\/jats:styled-content>: 0.60, 95% CI<\/jats:styled-content>: 0.52\u20100.67, P<\/jats:italic>\u00a0=\u00a0.01). PLSR<\/jats:styled-content> analysis of a linear combination of IPV<\/jats:styled-content> parameters yielded an AUC<\/jats:styled-content> of 0.79. Moreover, the IPV<\/jats:styled-content> ratio showed a greater clinical correlation with patient symptoms than conventional parameters.<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>The IPV<\/jats:styled-content> parameters and the combination of IPV<\/jats:styled-content> parameters via PLSR<\/jats:styled-content> were more significantly correlated with BE<\/jats:styled-content> time than the conventional parameters. Thus, this study presents a useful diagnostic tool for the evaluation of pathophysiologic abnormalities in dyssynergic defecation using IPV<\/jats:styled-content> and BE<\/jats:styled-content> time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13376","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T08:07:19Z","timestamp":1527149239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A high\u2010resolution anorectal manometry parameter based on integrated pressurized volume: A study based on 204 male patients with constipation and 26 controls"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-7380","authenticated-orcid":false,"given":"M.","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-3691","authenticated-orcid":false,"given":"K. W.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"},{"name":"Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Hallym College of Medicine Hallym University Sacred Heart Hospital Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. W.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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