{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:48:49Z","timestamp":1785883729098,"version":"3.56.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Electroacupuncture (EA<\/jats:styled-content>) has been shown to be effective in reducing symptoms in patients with functional dyspepsia (FD<\/jats:styled-content>). However, its mechanisms remain largely unknown. The aim of this study was to investigate mechanisms of the prokinetic effects of EA<\/jats:styled-content> in a rodent model of FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A FD<\/jats:styled-content> model was established by neonatal treatment of iodoacetamide (IA<\/jats:styled-content>). Eight weeks later, the rats were implanted with electrodes in the stomach for the measurement of gastric slow waves (GSW<\/jats:styled-content>) and electrodes into acupoints ST<\/jats:styled-content>36 for EA<\/jats:styled-content>. Autonomic functions were assessed by the spectral analysis of heart rate variability.<\/jats:p><\/jats:sec>Key Results<\/jats:title>(i) The IA<\/jats:styled-content>\u2010treated rats (\u201cFD<\/jats:styled-content>\u201d rats) showed increased dysrhythmia in both fasting and fed states (P<\/jats:italic>\u00a0<\u00a0.01) as well as during rectal distention (P<\/jats:italic>\u00a0<\u00a0.02). EA<\/jats:styled-content> reduced the percentage of dysrhythmia (P<\/jats:italic>\u00a0<\u00a0.05 for both fasting and fed) and normalized RD<\/jats:styled-content>\u2010induced impairment in GSW<\/jats:styled-content> in \u201cFD<\/jats:styled-content>\u201d rats. Atropine blocked the effect of EA<\/jats:styled-content> on GSW<\/jats:styled-content>. (ii) \u201cFD<\/jats:styled-content>\u201d rats showed delayed gastric emptying (P<\/jats:italic>\u00a0=\u00a0.001 vs control) that was accelerated with EA<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a0.01, vs sham\u2010EA<\/jats:styled-content>). (iii) \u201cFD<\/jats:styled-content>\u201d rats showed increased plasma norepinephrine (P<\/jats:italic>\u00a0=\u00a0.006, vs control) that was suppressed with EA<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a0.003) and reduced vagal activity that was improved with EA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>Gastric motility (GSW<\/jats:styled-content> and GE<\/jats:styled-content>) is impaired in rats treated with IA<\/jats:styled-content>, possibly attributed to impaired autonomic functions. EA<\/jats:styled-content> improves GSW<\/jats:styled-content> and accelerates GE<\/jats:styled-content> mediated via the autonomic and cholinergic mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13381","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T10:35:29Z","timestamp":1527849329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic\u2010cholinergic mechanisms in a rodent model of functional dyspepsia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-3177","authenticated-orcid":false,"given":"S.","family":"Zhang","sequence":"first","affiliation":[{"name":"Veterans Research and Education Foundation VA Medical Center Oklahoma City OK USA"},{"name":"Department of Physiology University of Oklahoma Health Science Center Oklahoma City OK USA"},{"name":"Department of Gastroenterology Tianjin No. 254 Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Li","sequence":"additional","affiliation":[{"name":"Veterans Research and Education Foundation VA Medical Center Oklahoma City OK USA"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins Center for Neurogastroenterology Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Veterans Research and Education Foundation VA Medical Center Oklahoma City OK USA"},{"name":"Department of Physiology University of Oklahoma Health Science Center Oklahoma City OK USA"},{"name":"Department of traditional Chinese medicine 1st Affiliated Hospital of Xi'an Jiao tong University Xi'an Shannxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ye","sequence":"additional","affiliation":[{"name":"Veterans Research and Education Foundation VA Medical Center Oklahoma City OK USA"},{"name":"Department of Physiology University of Oklahoma Health Science Center Oklahoma City OK USA"},{"name":"Department of Hepatology 1st Affiliated Hospital of Xi'an Jiao Tong University Xi'an Shannxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yin","sequence":"additional","affiliation":[{"name":"Veterans Research and Education Foundation VA Medical Center Oklahoma City OK USA"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins Center for Neurogastroenterology Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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