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No study has examined their emotional expressiveness as a marker of emotional reactivity. We investigated\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      patients\u2019 vulnerability to an emotional load by associating their expressiveness with psychological and neurophysiological assessments. We hypothesized that\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      would be characterized by a lack of expressiveness coupled with high scores in psychological and neurophysiological parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed the emotional facial expressions (\n                      <jats:styled-content style=\"fixed-case\">EMFACS<\/jats:styled-content>\n                      ), psychological (anxiety, depression, alexithymia), and neurophysiological (cortisol, heart rate variability (HRV)) parameters of 25\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      patients and 26 healthy controls (\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      ) while they watched fear\u2010eliciting movie extracts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Overall, the task elicited an increase in state anxiety and consistent HRV responses. However,\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      patients differed from\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      as they displayed more sadness and tended to display more rage. Contrary to\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      patients showed an increase in heart rate and a decrease in parasympathetic regulation, reflecting an enhanced responsiveness corroborated by higher scores in depression and state anxiety. Consistent with their higher difficulty in identifying feelings, a component of alexithymia positively correlated with their expressions of rage, they were not aware of their increase in anxiety during the task, whereas\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      were. No linear relationship between patients\u2019 expressions and their neurophysiological responses was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Irritable bowel syndrome patients displayed greater emotional expressiveness with negative prevalence. This reflects an emotional vulnerability potentially related to low regulation skills and underscores the importance of considering the central dysregulation hypothesis in\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      as a promising avenue of research.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13387","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T06:38:47Z","timestamp":1527835127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Emotional overactivity in patients with irritable bowel syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"A.","family":"Fournier","sequence":"first","affiliation":[{"name":"CNRS, LAPSCO Physiological and Psychosocial Stress University Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-6748","authenticated-orcid":false,"given":"L.","family":"Mondillon","sequence":"additional","affiliation":[{"name":"CNRS, LAPSCO Physiological and Psychosocial Stress University Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dantzer","sequence":"additional","affiliation":[{"name":"Laboratory of Psychology Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010S.","family":"Gauchez","sequence":"additional","affiliation":[{"name":"Biology Institute Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ducros","sequence":"additional","affiliation":[{"name":"Biology Institute Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University Hospital University Clinic of Hepato\u2010Gastroenterology  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Faure","sequence":"additional","affiliation":[{"name":"Biology Institute Grenoble Alpes University Hospital  Grenoble France"},{"name":"Grenoble Alpes University Hospital University Clinic of Hepato\u2010Gastroenterology  Grenoble France"},{"name":"Hypoxia Pathophysiology Laboratory (H2P, INSERM U1042)  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Canini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Operational Constraints Armed Forces Biomedical Research Institute  Br\u00e9tigny\u2010sur\u2010Orge France"},{"name":"Ecole du Val de Gr\u00e2ce  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bonaz","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University Hospital University Clinic of Hepato\u2010Gastroenterology  Grenoble France"},{"name":"Hypoxia Pathophysiology Laboratory (H2P, INSERM U1042)  Grenoble France"},{"name":"Department of Neurosciences and Operational Constraints Armed Forces Biomedical Research Institute  Br\u00e9tigny\u2010sur\u2010Orge France"},{"name":"Ecole du Val de Gr\u00e2ce  Paris France"},{"name":"Grenoble Institute of Neurosciences (GIN), INSERM University Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pellissier","sequence":"additional","affiliation":[{"name":"Univ. 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