{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:05:43Z","timestamp":1790489143465,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the last 30\u00a0years, non\u2010celiac gluten sensitivity (NCGS) has emerged as an intriguing and controversial topic in gastroenterology. The diagnosis of NCGS\/NCWS requires a symptomatic reaction to gluten, or wheat\u2010containing food, and remission of symptoms with gluten or wheat challenge, in patients in whom celiac disease and wheat allergy have been excluded. There have been several randomized clinical trials (RCT) addressing this issue which have produced controversial results. In this issue of Neurogastroenterology and Motility, a double\u2010blind placebo\u2010controlled randomized trial in patients with suspected NCGS on GFD, did not reproduce symptoms after gluten intake compared to placebo. This mini\u2010review addresses outstanding issues related to the diagnosis of NCGS\/NCWS as well as areas of interest for future studies that could explain, in part, the controversy in this area.<\/jats:p>","DOI":"10.1111\/nmo.13392","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T10:39:07Z","timestamp":1531996747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Non\u2010celiac gluten or wheat sensitivity: It's complicated!"],"prefix":"10.1111","volume":"30","author":[{"given":"Maria I.","family":"Pinto\u2010Sanchez","sequence":"first","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-2665","authenticated-orcid":false,"given":"Elena F.","family":"Verdu","sequence":"additional","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92427-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90432-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111268"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16069"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064966"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5103839"},{"key":"e_1_2_7_8_1","article-title":"The effect of a controlled gluten challenge in a group of patients with suspected non\u2010coeliac gluten sensitivity: a randomized, double\u2010blind placebo\u2010controlled challenge","volume":"30","author":"Dale HF","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-13"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/642452"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.809598"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000435546.87251.f7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750022995"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300248"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.21"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.054"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182942"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00225.2007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2017.09.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.487"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614529163"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04386.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509371767"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.03.025"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.153"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-23"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311964"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7031565"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02385.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312471"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.236"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.01.029"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064542"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2016.14.4.343"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1244705"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13372"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8020084"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.10.040"}],"container-title":["Neurogastroenterology &amp; 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