{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:24:40Z","timestamp":1780352680102,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH-SPARC (Stimulating Peripheral Activity for Relieving Conditions)","award":["U18TR001920"],"award-info":[{"award-number":["U18TR001920"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Functional gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) diseases are common and there are patients who are refractory to medical therapies as not all treatments work in all patients. Consequently, a large number of patients with functional<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>diseases use complementary and alternative medicine, such as acupuncture or electroacupuncture (<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>). In this issue, Zheng et\u00a0al. reported interesting results of a multi\u2010center placebo\u2010controlled clinical study on the use of<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>for treating refractory functional dyspepsia; another study reported a multi\u2010center clinical trial on<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>for chronic functional constipation; Liang et\u00a0al. studied mechanisms of<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>involving enteric nervous system and neurotransmitters in treating constipation in rats. While controversial reports are available in the literature,<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>with appropriate methodologies as shown in these recent studies is believed to be effective in treating certain functional<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>diseases. In this mini\u2010review, a number of clinical studies, including those included in this issue on the use of<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>for treating gastro\u2010esophageal reflux, functional dyspepsia, irritable bowel syndrome, and constipation are reviewed. Some critically important issues, such as the choice of stimulation parameters for<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>, the administration frequency of the therapy, and the appropriate choice of placebo for clinical research are also discussed. Mechanisms of action involved in the therapeutic effects of<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>for gut dysmotility and future research directions are also presented.<\/jats:p>","DOI":"10.1111\/nmo.13393","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T18:33:26Z","timestamp":1529087606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Electroacupuncture treatments for gut motility disorders"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-5697","authenticated-orcid":false,"given":"J. D. 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