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Polymodal sensory receptors like the TRP<\/jats:styled-content> or ASIC<\/jats:styled-content> family receptors are potential targets to treat OD<\/jats:styled-content>. TRPM<\/jats:styled-content>8 agonists and acidic solutions can improve the swallow response in patients with OD<\/jats:styled-content>, but little is known about the expression of TRPM<\/jats:styled-content>8, ASIC<\/jats:styled-content>1, and ASIC<\/jats:styled-content>3 in the human oropharynx. The aim of this study was to assess the expression and localization of TRPM<\/jats:styled-content>8, ASIC<\/jats:styled-content>1, and ASIC<\/jats:styled-content>3 in human samples of the oropharynx to lay the basis for new pharmacological treatments for OD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Pathology\u2010free samples from oropharyngeal regions innervated by cranial nerves V, IX<\/jats:styled-content>, and X were obtained during major ENT<\/jats:styled-content> surgery and processed to obtain mRNA<\/jats:styled-content> (20 patients) or to be used in immunohistochemical assays (12 patients). TRPM<\/jats:styled-content>8, ASIC<\/jats:styled-content>1, and ASIC<\/jats:styled-content>3 expression and localization were studied with RT<\/jats:styled-content>\u2010qPCR<\/jats:styled-content> and fluorescent immunohistochemistry.<\/jats:p><\/jats:sec>Key Results<\/jats:title>ASIC<\/jats:styled-content>3 was expressed in the 3 regions studied with similar levels and was localized on sensory fibers innervating the mucosa below the basal lamina of all studied regions. TRPM<\/jats:styled-content>8 was also co\u2010localized on the sensory fibers innervating the mucosa below the basal lamina of all studied regions. In contrast, ASIC<\/jats:styled-content>1 was only found in the nerves innervating the tongue muscular fibers.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>TRPM<\/jats:styled-content>8 and ASIC<\/jats:styled-content>3 are found on submucosal sensory nerves in the human oropharynx. Our study lays the basis to use oropharyngeal TRPM<\/jats:styled-content>8 and ASIC<\/jats:styled-content>3 receptors as therapeutic targets to develop new active pharmacological treatments for OD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13398","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T08:21:18Z","timestamp":1530692478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["TRPM<\/scp>8, ASIC<\/scp>1, and ASIC<\/scp>3 localization and expression in the human oropharynx"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-0793","authenticated-orcid":false,"given":"D.","family":"Alvarez\u2010Berdugo","sequence":"first","affiliation":[{"name":"Gastrointestinal Motility Laboratory Hospital de Matar\u00f3 Consorci Sanitari del Maresme Matar\u00f3 Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rofes","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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