{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:28:47Z","timestamp":1788553727381,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Esophageal stasis is a hallmark of achalasia. Timed barium esophagogram (TBE<\/jats:styled-content>) is used to measure stasis but exposes patients to ionizing radiation. It is suggested that esophageal stasis can be objectified on high\u2010resolution manometry (HRM<\/jats:styled-content>) as well using a rapid drinking challenge test (RDC<\/jats:styled-content>). We aimed to assess esophageal stasis in achalasia by a RDC<\/jats:styled-content> during HRM<\/jats:styled-content> and compare this to TBE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty healthy subjects (15 male, age 40 [IQR<\/jats:styled-content> 34\u201049]) and 90 achalasia patients (53 male, age 47 [36\u201059], 30 untreated\/30 treated symptomatic\/30 treated asymptomatic) were prospectively included to undergo HRM<\/jats:styled-content> with RDC<\/jats:styled-content> and TBE<\/jats:styled-content>. RDC<\/jats:styled-content> was performed by drinking 200\u00a0mL of water. Response to RDC<\/jats:styled-content> was measured by basal and relaxation pressure in the esophagogastric junction (EGJ<\/jats:styled-content>) and esophageal pressurization during the last 5\u00a0seconds.<\/jats:p><\/jats:sec>Key Results<\/jats:title>EGJ<\/jats:styled-content> basal and relaxation pressure during RDC<\/jats:styled-content> were higher in achalasia compared to healthy subjects (overall P<\/jats:italic>\u00a0<\u00a0.01). Esophageal body pressurization was significantly higher in untreated (43 [33\u201035\u00a0mm Hg]) and symptomatic treated patients (25 [16\u201032] mm Hg) compared to healthy subjects (6 [3\u20107] mm Hg) and asymptomatic treated patients (11 [8\u201015] mm Hg, overall P<\/jats:italic>\u00a0<\u00a0.01). A strong correlation was observed between esophageal pressurization during RDC<\/jats:styled-content> and barium column height at 5\u00a0minutes on TBE<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a0.75, P<\/jats:italic>\u00a0<\u00a0.01), comparable to the standard predictor of esophageal stasis, IRP<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a0.66, P<\/jats:italic>\u00a0<\u00a0.01).<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>The RDC<\/jats:styled-content> can reliably predict esophageal stasis in achalasia and adequately measure treatment response to a degree comparable to TBE<\/jats:styled-content>. We propose to add this simple test to each HRM<\/jats:styled-content> study in achalasia patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13404","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T09:51:49Z","timestamp":1531216309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Rapid drinking challenge during high\u2010resolution manometry is complementary to timed barium esophagogram for diagnosis and follow\u2010up of achalasia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-3171","authenticated-orcid":false,"given":"F. A.","family":"Ponds","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Oors","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00661.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.61"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.145"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.765"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.318"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00444.2005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00886.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01273.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12749"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12902"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.130"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01971.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12310"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.181"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(18)30071-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00447.2013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.2.9242756"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00980.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.196"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00814.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30035.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(17)32425-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13021"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615584732"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2008.00914.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640613492157"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T06:18:03Z","timestamp":1694845083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/nmo.13404"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13404","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,10]]},"assertion":[{"value":"2018-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13404"}}