{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:09:34Z","timestamp":1759230574723,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novo Nordisk Scandinavia AS"},{"name":"Empowering Industry and Research EIR Northern Jutland"},{"name":"Innovation Fund Denmark, Individuals, Disease and Society, Copenhagen, Denmark","award":["10-092786"],"award-info":[{"award-number":["10-092786"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Gastrointestinal (GI<\/jats:styled-content>) symptoms, such as nausea and bloating, are common in people with type 1 diabetes (T1DM<\/jats:styled-content>). Autonomic dysfunction can lead to changes in the GI<\/jats:styled-content> secreto\u2010motor function which can be associated with GI<\/jats:styled-content> symptom development. We hypothesized that regional pH<\/jats:styled-content> profiles in T1DM<\/jats:styled-content> differs from health and would be associated with objective physiological\/clinical markers.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010seven T1DM<\/jats:styled-content> with confirmed diabetic sensory peripheral neuropathy and 41 healthy age\u2010matched subjects underwent standardized wireless motility capsule testing. T1DM<\/jats:styled-content> completed the gastroparesis cardinal symptom index (GCSI<\/jats:styled-content>) and the gastrointestinal symptom rating scale. Disease duration, glycemic control, insulin usage, and 24\u2010hour heart rate variability testing were evaluated.<\/jats:p><\/jats:sec>Key Results<\/jats:title>In comparison to healthy subjects, gastric, and large bowel median pH<\/jats:styled-content> were lower in T1DM<\/jats:styled-content> (1.8\u00a0\u00b1\u00a01.6 vs 2.9\u00a0\u00b1\u00a01.5, P<\/jats:italic>\u00a0=\u00a00.001 and 6.7\u00a0\u00b1\u00a00.6 vs 7.0\u00a0\u00b1\u00a00.5, P<\/jats:italic>\u00a0=\u00a00.003, respectively). Additionally, change in pH<\/jats:styled-content> across the pylorus was lower while change in pH<\/jats:styled-content> across the ileocecal junction was higher in T1DM<\/jats:styled-content> (5.2\u00a0\u00b1\u00a01.5 vs 5.8\u00a0\u00b1\u00a00.5, P<\/jats:italic>\u00a0=\u00a00.003 and 1.8\u00a0\u00b1\u00a00.4 vs 1.3\u00a0\u00b1\u00a00.4, P<\/jats:italic>\u00a0<\u00a00.0001, respectively). No difference was found in small bowel median pH<\/jats:styled-content>. Gastric median pH<\/jats:styled-content> was associated with small bowel transit time (r<\/jats:italic>\u00a0=\u00a00.30, P<\/jats:italic>\u00a0=\u00a00.049). Change in pH<\/jats:styled-content> across the pylorus was negatively associated with fasting glycose (r<\/jats:italic>\u00a0=\u00a0\u22120.35, P<\/jats:italic>\u00a0=\u00a00.027). Small bowel median pH<\/jats:styled-content> was associated with nausea (r<\/jats:italic>\u00a0=\u00a00.42, P<\/jats:italic>\u00a0=\u00a00.005) and small bowel transit time (r<\/jats:italic>\u00a0=\u00a00.48, P<\/jats:italic>\u00a0=\u00a00.0007). Large bowel median pH<\/jats:styled-content> was associated with nausea (r<\/jats:italic>\u00a0=\u00a00.35, P<\/jats:italic>\u00a0=\u00a00.018) and the total GCSI<\/jats:styled-content> score (r<\/jats:italic>\u00a0=\u00a00.34, P<\/jats:italic>\u00a0=\u00a00.023).<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>The GI pH<\/jats:styled-content> profile in T1DM<\/jats:styled-content> with DSPN<\/jats:styled-content> is different from healthy subjects. Changes in pH<\/jats:styled-content> profile may have important therapeutic implications and influence pharmacotherapeutic bioavailability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13407","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T04:59:43Z","timestamp":1533013183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Regional gastrointestinal pH<\/scp> profile is altered in patients with type 1 diabetes and peripheral neuropathy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-4843","authenticated-orcid":false,"given":"A.\u2010M. L.","family":"Wegeberg","sequence":"first","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg and Clinical Institute Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-1884","authenticated-orcid":false,"given":"C.","family":"Brock","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg and Clinical Institute Aalborg University Aalborg Denmark"},{"name":"Department of Pharmacotherapy and Development University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-6023","authenticated-orcid":false,"given":"B.","family":"Brock","sequence":"additional","affiliation":[{"name":"Steno Diabetes Centre Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-2640","authenticated-orcid":false,"given":"A. D.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg and Clinical Institute Aalborg University Aalborg Denmark"},{"name":"Department of Gastroenterology University Hospitals of North Midlands Stoke on Trent Staffordshire UK"},{"name":"Academic Surgical Unit & Neurogastroenterology Group Centre for Neuroscience and Trauma Blizard Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Hobson","sequence":"additional","affiliation":[{"name":"The Functional Gut Clinic London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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