{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:15:15Z","timestamp":1777709715298,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health & Medical Research Council Senior Research Fellowship"},{"name":"Termeulen Fund"},{"name":"the College of Medicine and Public Health, Flinders University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010resolution impedance manometry (HRIM) allows evaluation of esophageal bolus retention, flow, and pressurization. We explored novel HRIM measures and assessed their temporal relationship to dysphagia symptoms for boluses of different volume and consistency in non\u2010obstructive dysphagia (NOD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three NOD patients (n\u00a0=\u00a019 minor or no disorder of peristalsis (\u201cNormal\u201d) and n\u00a0=\u00a014 esophagogastric junction outflow obstruction (\u201cEGJOO\u201d)) were evaluated with HRIM. Patients were administered 5 and 10\u00a0mL liquid, semisolid, and 2 and 4\u00a0cm solid boluses and indicated bolus perception during individual swallows using a 5\u2010point Likert scale. HRIM was analyzed to assess Chicago Classification and pressure flow metrics, esophageal impedance integral (EII) ratio, and bolus flow time (BFT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Overall, bolus perception increased with increasing bolus consistency (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but did not differ significantly between EGJOO and Normal patients. EGJOO patients had higher IRP4, higher levels of bolus residual (ie, EII ratio and IR), and restricted esophageal emptying. The results for linking semisolid bolus perception to semisolid\u2010derived measures revealed more biomechanically plausible and consistent patterns when compared to those derived for liquid boluses. In Normal patients, perception of boluses of heavier viscosity was related to higher bolus flow resistance during transport, whilst in EGJOO, perception was related to restriction of esophageal emptying.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>These novel pressure\u2010impedance measures may aid in the evaluation of NOD patients by revealing abnormal motor patterns, which may explain symptom generation. Future studies are needed to evaluate which of these measures are worthy of calculation and to establish protocol settings that allow for their meaningful interpretation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13505","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T05:30:33Z","timestamp":1542173433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["High\u2010resolution impedance manometry parameters in the evaluation of esophageal function of non\u2010obstructive dysphagia patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-4790","authenticated-orcid":false,"given":"Maartje J.","family":"Singendonk","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children\u2019s Hospital\/Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-6952","authenticated-orcid":false,"given":"Zhiyue","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Scheerens","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, ExpORL University of Leuven Leuven Belgium"},{"name":"Translational Research Center for Gastrointestinal Diseases University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Diseases University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"Dustin A.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7378","authenticated-orcid":false,"given":"Taher I.","family":"Omari","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, ExpORL University of Leuven Leuven Belgium"},{"name":"School of Medicine Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, ExpORL University of Leuven Leuven Belgium"},{"name":"Translational Research Center for Gastrointestinal Diseases University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12040"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12308"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12613"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00119.2014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13289"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12941"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.12.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12346"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12369"},{"issue":"8","key":"e_1_2_10_11_1","first-page":"1416","article-title":"Long\u2010term Outcomes of Patients With Normal or Minor Motor Function Abnormalities Detected by High\u2010resolution Esophageal Manometry","volume":"13","author":"Ravi K","year":"2015","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.3.796"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9729-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12176"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01938.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-3000-3"}],"container-title":["Neurogastroenterology &amp; 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