{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:45:44Z","timestamp":1787737544053,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Confirming treatment response in clinical trials for irritable bowel syndrome (IBS) is challenging, due to the lack of biomarkers and limitations of the currently available symptom assessment tools. The Experience Sampling Method (ESM) might overcome these limitations by collecting digital assessments randomly and repeatedly during daily life. This study evaluated differences in change in abdominal pain between real\u2010time (ie, ESM) and retrospective (ie<jats:italic>,<\/jats:italic> Gastrointestinal Symptom Rating Scale [GSRS] and an end\u2010of\u2010day symptom diary) measurements, using data of an RCT on escitalopram vs placebo in patients with IBS and comorbid panic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine IBS patients with comorbid panic disorder were included in a 6\u2010month RCT. The GSRS, diary, and ESM were completed at baseline (t\u00a0=\u00a00) and after 3 (t\u00a0=\u00a03) and 6\u00a0months (t\u00a0=\u00a06). Linear mixed models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Experience Sampling Method analyses revealed a significant interaction between escitalopram and time, and ESM abdominal pain scores were 1.4 points lower in the escitalopram group compared to placebo at t\u00a0=\u00a06 (on a 1\u2010to\u20107 scale; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). When including the interaction with momentary anxiety, the reduction in abdominal pain scores in escitalopram vs placebo was even more pronounced for higher levels of anxiety. Average GSRS\u2010 and end\u2010of\u2010day abdominal pain scores were not significantly different between escitalopram and placebo at t\u00a0=\u00a03 and 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Real\u2010time ESM has the potential to capture treatment response more sensitively compared to a retrospective end\u2010of\u2010day GI symptom diary and the GSRS, by taking into account day\u2010to\u2010day symptom variability as well as momentary factors that might moderate treatment effect, such as anxiety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13515","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T02:00:27Z","timestamp":1542765627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Experience Sampling Method\u2014Evaluation of treatment effect of escitalopram in IBS with comorbid panic disorder"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-3191","authenticated-orcid":false,"given":"Lisa","family":"Vork","sequence":"first","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology, Department of Internal Medicine NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-0381","authenticated-orcid":false,"given":"Zlatan","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology, Department of Internal Medicine NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Drukker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology, Department of Internal Medicine NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Conchillo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology, Department of Internal Medicine NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine A. 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