{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:25:34Z","timestamp":1784226334776,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1278018N (Ans Pauwels)"],"award-info":[{"award-number":["1278018N (Ans Pauwels)"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Senior clinical investigator (Tim Vanuytsel)"],"award-info":[{"award-number":["Senior clinical investigator (Tim Vanuytsel)"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Itopride, a prokinetic with dopamine D2\u2010antagonistic and cholinesterase inhibitor properties, is used for treating functional dyspepsia (FD) patients. However, the effects of itopride on sensitivity to gastric distention and impaired gastric accommodation, major pathophysiological mechanisms of FD, are unknown. Our aim was to evaluate the effect of itopride on gastric distention and on gastric accommodation in healthy volunteers, compared to placebo and domperidone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen healthy volunteers (6 male, mean age 28.3\u00a0\u00b1\u00a05.8) were studied after pretreatment for 2\u00a0days tid with placebo (P), itopride 50\u00a0mg (I50), itopride 100\u00a0mg (I100), or domperidone 10\u00a0mg (D10) in a placebo\u2010controlled, double\u2010blind cross\u2010over design. A gastric barostat study was performed to assess gastric compliance, sensitivity to gastric distention, and gastric accommodation. Symptoms were evaluated by visual analogue scales and perception scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>I50, I100, and D10 did not influence gastric compliance and sensitivity compared to placebo. No significant differences in accommodation were observed after I100 compared to P. Preprandial intragastric volumes were similar with D10, I50, or placebo (respectively, 244\u00a0\u00b1\u00a021, 225\u00a0\u00b1\u00a023, and 261\u00a0\u00b1\u00a036\u00a0mL, NS). However, postprandial gastric volumes were lower after I50 compared to placebo (303\u00a0\u00b1\u00a034 vs. 448\u00a0\u00b1\u00a050\u00a0mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Gastric accommodation was significantly reduced after D10 (90\u00a0\u00b1\u00a026\u00a0mL) and I50 (78\u00a0\u00b1\u00a025\u00a0mL) compared to placebo (186\u00a0\u00b1\u00a037\u00a0mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In healthy subjects, itopride and domperidone do not alter gastric compliance or sensitivity. I50 and D10 three times daily, but not I100, decrease meal\u2010related gastric accommodation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13544","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T01:03:18Z","timestamp":1548982998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of itopride and domperidone on gastric tone and on the perception of gastric distention in healthy subjects"],"prefix":"10.1111","volume":"31","author":[{"given":"Karen","family":"Van den Houte","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven 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