{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:46:06Z","timestamp":1793353566956,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (IBS) is among the most common gastrointestinal disorders, and a substantial proportion of patients have an insufficient response to treatment. In a single\u2010blinded study, sacral nerve modulation (SNM) significantly reduced symptoms of IBS. The aim of the present double\u2010blinded, randomized, placebo\u2010controlled study was to evaluate the effect of SNM for IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients with diarrhea\u2010predominant or mixed IBS and a minimum baseline IBS\u2010specific symptom score of 40 points (Gastrointestinal Symptom Rating Scale\u2010IBS version). Patients underwent a 6\u2010week period of SNM. In the first 4\u00a0weeks, the patients were randomized 1:1 to have the neurostimulator set subsensory or OFF for 2\u00a0weeks and then the opposite for another 2\u00a0weeks. Patients and investigators were blinded to settings. In the remaining 2\u00a0weeks, the stimulation was set suprasensory. IBS\u2010specific symptoms and quality of life were assessed with validated questionnaires and bowel diaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Twenty\u2010one patients were randomized and eligible for analysis. The IBS\u2010specific symptom score was reduced with borderline significance during stimulation (subsensory\u2010OFF median change \u22121 (\u221226, 9), OFF\u2010subsensory median change 8 (\u221211, 36); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0572). Pain was significantly reduced during stimulation (subsensory\u2010OFF median change \u22121.5 (\u22124, 1), OFF\u2010subsensory median change 1 (\u22124, 3); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0188), along with the number of daily bowel movements (subsensory\u2010OFF median change 0 (\u22121.8, 0.2), OFF\u2010subsensory median change 0.2 (\u22120.5, 1.1); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0373). The median placebo effect was 14% (0, 55).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>Sacral nerve modulation for IBS seems promising but should be considered experimental until larger multicenter studies have been performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13570","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T05:02:20Z","timestamp":1550811740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sacral nerve modulation for irritable bowel syndrome: A randomized, double\u2010blinded, placebo\u2010controlled crossover study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-223X","authenticated-orcid":false,"given":"Janne","family":"Fassov","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilli","family":"Lundby","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Krogh","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_9_3_1","article-title":"Rome IV diagnostic questionnaires and tables for investigators and clinicians","volume":"13","author":"Palsson OS","year":"2016","journal-title":"Gastroenterology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01456.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.181"},{"key":"e_1_2_9_6_1","first-page":"727","article-title":"The global impact of IBS: time to think about IBS\u2010specific models of care?","volume":"10","author":"Corsetti M","year":"2017","journal-title":"Therap Adv"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12929"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02623.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000559"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13428"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834bb951"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310004209"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200504000-00004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.187989"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10326"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000653"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9391"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60314-2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.330"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-111"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03148.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12426"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02518.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0548-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318247d49f"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12987"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12450"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5111"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182196ff4"},{"key":"e_1_2_9_31_1","unstructured":"http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2014\/09\/WC500173457.pdf. 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