{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T12:43:15Z","timestamp":1772368995197,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","award":["AO GIRCI 2012"],"award-info":[{"award-number":["AO GIRCI 2012"]}],"id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Botulinum toxin injection is known to be efficient to treat achalasia. We conducted a randomized trial in order to evaluate its efficacy to treat symptomatic hypercontractile esophageal disorders as characterized by esophageal high\u2010resolution manometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with significant dysphagia and\/or thoracic pain related to an hypercontractile esophageal motility disorder as defined by the Chicago Classification were randomized to receive an injection of botulinum toxin (100\u00a0U in 10 points in the distal part of the esophageal wall) or a sham procedure. Symptoms were assessed at 3\u00a0months with the Eckardt score. Patients could receive a first or second botulinum toxin injection 1\u00a0month later if symptoms persisted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010three patients (13 women, mean age 60\u00a0years) were included: 13 received botulinum toxin injection, and 10 a sham procedure. The improvement of symptoms at 3\u00a0months was significant compared to baseline, but similar in the active treatment and sham procedure arms. However, there was no change in quality of life scores. Seventeen patients received a second injection at 4\u00a0months. There was a significant trend toward improvement of symptoms up to the end of follow\u2010up at 12\u00a0months, without a significant relationship with the administration of botulinum toxin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Botulinum toxin injection is not superior to a sham procedure to improve symptoms related to hypercontractile esophageal disorders, suggesting an important placebo effect in for this type of disease. This observation must be taken into account when evaluating more aggressive therapies such as endoscopic myotomy (clinicaltrials.gov: NCT01955174).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13587","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:14:33Z","timestamp":1555028073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Botulinum toxin for the treatment of hypercontractile esophagus: Results of a double\u2010blind randomized sham\u2010controlled study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-1591","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Mion","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon, Hospital E. Herriot Digestive Physiology Lyon France"},{"name":"Physiology Department Universit\u00e9 de Lyon Lyon France"},{"name":"LabTau INSERM U1032 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Marjoux","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Hospital E. Herriot Digestive Physiology Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Subtil","sequence":"additional","affiliation":[{"name":"Biostatistics Department Hospices Civils de Lyon, Hospital E. Herriot Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Gastroenterology Hospices Civils de Lyon, Hospital E. Herriot Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Rivory","sequence":"additional","affiliation":[{"name":"Gastroenterology Hospices Civils de Lyon, Hospital E. Herriot Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7638","authenticated-orcid":false,"given":"Sabine","family":"Roman","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Hospital E. Herriot Digestive Physiology Lyon France"},{"name":"Physiology Department Universit\u00e9 de Lyon Lyon France"},{"name":"LabTau INSERM U1032 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Zerbib","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Gastroenterology Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000187"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00342.2018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70206-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0016-5085(82)80062-0","article-title":"Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation","volume":"83","author":"Gelfond M","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005672"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321203"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02093606"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.119256"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-008-9159-y"},{"issue":"139","key":"e_1_2_8_13_1","first-page":"e27","article-title":"Botulinum toxin injection in dysphagia syndromes with preserved esophageal peristalsis and incomplete lower esophageal sphincter relaxation","volume":"23","author":"Porter RF","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2012.60.2.109"},{"issue":"1115","key":"e_1_2_8_15_1","first-page":"e2","article-title":"Botulinum toxin reduces dysphagia in patients with nonachalasia primary esophageal motility disorders","volume":"11","author":"Vanuytsel T","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"e_1_2_8_16_1","first-page":"E405","article-title":"Fatal mediastinitis following botulinum toxin injection for esophageal spasm","volume":"45","author":"Marjoux S","year":"2013","journal-title":"Endoscopy"},{"key":"e_1_2_8_17_1","first-page":"1","article-title":"Complications of botulinum toxin injections for treatment of esophageal motility disorders","volume":"30","author":"Hoeij FB","year":"2017","journal-title":"Dis Esophagus"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000317"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91428-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70137-5"},{"key":"e_1_2_8_21_1","first-page":"25","article-title":"First validation of the French version of the Gastrointestinal Quality of Life Index (GIQLI)","volume":"23","author":"Slim K","year":"1999","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0318-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13105"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002311"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.317"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2014.64.6.370"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.958096"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-105204"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-115887"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1424933"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.154"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12282"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0532-y"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12902"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30148-6"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.13587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T17:49:10Z","timestamp":1694368150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/nmo.13587"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13587","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735535194.793561168","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]},"assertion":[{"value":"2019-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13587"}}