{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:43:56Z","timestamp":1785519836314,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate measurement of anal sphincter function is potentially of value in defining treatment of common pelvic floor disorders. The aim of this study was to establish repeatability and validate high\u2010resolution anorectal manometry (HRAM) by comparison to conventional manometry (CM). Arising from this work would be definitive normal range data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty healthy volunteers (40 female) underwent a test\u2010retest repeatability study. A 16\u2010channel water\u2010perfused HRAM catheter was compared to an 8\u2010channel conventional catheter using a station pull\u2010through technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>High\u2010resolution anorectal manometry had similar precision to conventional manometry when measuring resting pressure (intraclass correlation coefficient [ICC] 0.73 vs 0.68, HRAM vs CM) and squeeze increment (ICC 0.90 vs 0.94, HRAM vs CM). HRAM measured resting pressures 10% lower than CM and squeeze pressure 27% higher than CM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>High\u2010resolution anorectal manometry is a valid technique with comparable precision to CM. HRAM measurements differ considerably to CM, and a new set of normal values must be used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13591","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T05:36:11Z","timestamp":1557984971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["High\u2010resolution anal manometry: Repeatability, validation, and comparison with conventional manometry"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-8596","authenticated-orcid":false,"given":"Jonathan","family":"Gosling","sequence":"first","affiliation":[{"name":"Department of Specialist X\u2010Ray University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Plumb","sequence":"additional","affiliation":[{"name":"Department of Specialist X\u2010Ray University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Specialist X\u2010Ray University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton V.","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000514"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70195-2"},{"key":"e_1_2_9_4_1","unstructured":"Institute National for Health and Care Excellence. 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