{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:54:07Z","timestamp":1783644847998,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acupuncture has been widely accepted for treatments of many diseases. This study was performed to determine effects and mechanisms of electroacupuncture (EA) by chronically implanted electrodes at acupoint ST36 on colonic inflammation induced by TNBS in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After intrarectal administration of TNBS, the rats were treated with sham\u2010EA, EA1\/EA2 (two sets of parameters) for 3\u00a0weeks. Disease activity index (DAI), macroscopic and microscopic lesions, plasma levels of TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106 were observed as evaluation of inflammatory responses. The autonomic function was assessed by analysis of the heart rate variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(a) Vagal activity was significantly increased with both acute and chronic EA1\/EA2; (b) DAI was significantly decreased with both chronic EA1 and EA2, and EA2 was more potent than EA1 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); (c) The macroscopic score was 6.4\u00a0\u00b1\u00a00.6 with sham\u2010EA and reduced to 4.9\u00a0\u00b1\u00a00.1 with EA1 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and 4.0\u00a0\u00b1\u00a00.2 with EA2 (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The histological score was 4.05\u00a0\u00b1\u00a00.58 with sham\u2010EA and remained unchanged (3.71\u00a0\u00b1\u00a00.28) with EA1 (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) but reduced to 3.0\u00a0\u00b1\u00a00.3 with EA2 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01); (d) The plasma levels of TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106 were significantly decreased with EA2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Electrical stimulation at ST36 improves colonic inflammation in TNBS\u2010treated rats by inhibiting pro\u2010inflammatory cytokines via the autonomic mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13615","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T23:28:56Z","timestamp":1558567736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Autonomically mediated anti\u2010inflammatory effects of electrical stimulation at acupoints in a rodent model of colonic inflammation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-9377","authenticated-orcid":false,"given":"Haifeng","family":"Jin","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center Veterans Research and Education Foundation Oklahoma City Oklahoma"},{"name":"The First Affiliated Hospital of Zhejiang Chinese Medicine University Hangzhou China"},{"name":"University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5003-9785","authenticated-orcid":false,"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore Maryland"},{"name":"The First Hospital of Wuhan Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemin","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore Maryland"},{"name":"Guizhou Provincial People's Hospital Guizhou, Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-571X","authenticated-orcid":false,"given":"Bin","family":"Lyu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medicine University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Foreman","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohong","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore Maryland"},{"name":"The First Hospital of Wuhan Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyun","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-5697","authenticated-orcid":false,"given":"Jiande D. Z.","family":"Chen","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center Veterans Research and Education Foundation Oklahoma City Oklahoma"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.055"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00603.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198810000-00007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828028ca"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1995-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01320"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22957"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13461"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01989.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.5.617"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-5-200203050-00010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i5.1028"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2007.11.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000030081.91006.86"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.10.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069424"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00272.2001"},{"issue":"9","key":"e_1_2_9_21_1","first-page":"1527","article-title":"Electrical stimulation of acupuncture points enhances gastric myoelectrical activity in humans","volume":"92","author":"Lin X","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90322.2008"},{"issue":"12","key":"e_1_2_9_23_1","first-page":"3215","article-title":"An optimized IES method and its inhibitory effects and mechanisms on food intake and body weight in diet\u2010induced obese rats: IES for obesity","volume":"27","author":"Wan X","year":"2017","journal-title":"Obes Surg"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.016"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01067-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06563.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00252.2009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i31.11000"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078151"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36636"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/942196"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy371"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-014-1521-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0369"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100301.064816"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.2.203"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.09.026"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f37a"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1692"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13850"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.1.33"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20342"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.3.618.618"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(09)60033-9"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9561-y"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06719.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2004.5.3.189"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7710"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5234.283"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013070"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01252.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.13615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T13:33:09Z","timestamp":1694266389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/nmo.13615"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13615","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"2018-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13615"}}